Literature DB >> 34266732

Redefining actin dynamics of the pointed-end complex in striated muscle.

Jessika Iwanski1, Carol C Gregorio2, Mert Colpan1.   

Abstract

Striated muscle is intricately designed to provide efficient and powerful muscle contractions. Recently, a long sought-after missing component of the thin filament pointed-end machinery was discovered: cyclase-associated protein 2 (CAP2). CAP2 was identified as a crucial contributor to actin polymerization, striated muscle development, and severe muscle disease when mutated.
Copyright © 2021 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  actin; muscle; myopathy; sarcomere; thin filament

Mesh：

Substances：

Year:  2021        PMID： 34266732      PMCID： PMC8787868          DOI： 10.1016/j.tcb.2021.06.006

Source DB:  PubMed          Journal:  Trends Cell Biol        ISSN： 0962-8924            Impact factor:   20.808


  14 in total

1.  CAP2 mutation leads to impaired actin dynamics and associates with supraventricular tachycardia and dilated cardiomyopathy.

Authors:  Liam Aspit; Aviva Levitas; Sharon Etzion; Hanna Krymko; Leonel Slanovic; Raz Zarivach; Yoram Etzion; Ruti Parvari
Journal:  J Med Genet       Date:  2018-12-05       Impact factor: 6.318

Review 2.  Tropomodulins and Leiomodins: Actin Pointed End Caps and Nucleators in Muscles.

Authors:  Velia M Fowler; Roberto Dominguez
Journal:  Biophys J       Date:  2017-05-09       Impact factor: 4.033

3.  Leiomodin-3 dysfunction results in thin filament disorganization and nemaline myopathy.

Authors:  Michaela Yuen; Sarah A Sandaradura; James J Dowling; Alla S Kostyukova; Natalia Moroz; Kate G Quinlan; Vilma-Lotta Lehtokari; Gianina Ravenscroft; Emily J Todd; Ozge Ceyhan-Birsoy; David S Gokhin; Jérome Maluenda; Monkol Lek; Flora Nolent; Christopher T Pappas; Stefanie M Novak; Adele D'Amico; Edoardo Malfatti; Brett P Thomas; Stacey B Gabriel; Namrata Gupta; Mark J Daly; Biljana Ilkovski; Peter J Houweling; Ann E Davidson; Lindsay C Swanson; Catherine A Brownstein; Vandana A Gupta; Livija Medne; Patrick Shannon; Nicole Martin; David P Bick; Anders Flisberg; Eva Holmberg; Peter Van den Bergh; Pablo Lapunzina; Leigh B Waddell; Darcée D Sloboda; Enrico Bertini; David Chitayat; William R Telfer; Annie Laquerrière; Carol C Gregorio; Coen A C Ottenheijm; Carsten G Bönnemann; Katarina Pelin; Alan H Beggs; Yukiko K Hayashi; Norma B Romero; Nigel G Laing; Ichizo Nishino; Carina Wallgren-Pettersson; Judith Melki; Velia M Fowler; Daniel G MacArthur; Kathryn N North; Nigel F Clarke
Journal:  J Clin Invest       Date:  2014-09-24       Impact factor: 14.808

4.  Knockout of Lmod2 results in shorter thin filaments followed by dilated cardiomyopathy and juvenile lethality.

Authors:  Christopher T Pappas; Rachel M Mayfield; Christine Henderson; Nima Jamilpour; Cathleen Cover; Zachary Hernandez; Kirk R Hutchinson; Miensheng Chu; Ki-Hwan Nam; Jose M Valdez; Pak Kin Wong; Henk L Granzier; Carol C Gregorio
Journal:  Proc Natl Acad Sci U S A       Date:  2015-10-20       Impact factor: 11.205

5.  Cyclase-associated protein 1 (CAP1) promotes cofilin-induced actin dynamics in mammalian nonmuscle cells.

Authors:  Enni Bertling; Pirta Hotulainen; Pieta K Mattila; Tanja Matilainen; Marjo Salminen; Pekka Lappalainen
Journal:  Mol Biol Cell       Date:  2004-03-05       Impact factor: 4.138

6.  Ablation of cyclase-associated protein 2 (CAP2) leads to cardiomyopathy.

Authors:  Vivek S Peche; Tad A Holak; Bhagyashri D Burgute; Kosmas Kosmas; Sushant P Kale; F Thomas Wunderlich; Fatiha Elhamine; Robert Stehle; Gabriele Pfitzer; Klaus Nohroudi; Klaus Addicks; Florian Stöckigt; Jan W Schrickel; Julia Gallinger; Michael Schleicher; Angelika A Noegel
Journal:  Cell Mol Life Sci       Date:  2012-09-04       Impact factor: 9.261

7.  CAP2 deficiency delays myofibril actin cytoskeleton differentiation and disturbs skeletal muscle architecture and function.

Authors:  Lara-Jane Kepser; Fidan Damar; Teresa De Cicco; Christine Chaponnier; Tomasz J Prószyński; Axel Pagenstecher; Marco B Rust
Journal:  Proc Natl Acad Sci U S A       Date:  2019-04-08       Impact factor: 11.205

8.  Disruption of cardiac thin filament assembly arising from a mutation in LMOD2: A novel mechanism of neonatal dilated cardiomyopathy.

Authors:  Rebecca C Ahrens-Nicklas; Christopher T Pappas; Gerrie P Farman; Rachel M Mayfield; Tania M Larrinaga; Livija Medne; Alyssa Ritter; Ian D Krantz; Chaya Murali; Kimberly Y Lin; Justin H Berger; Sabrina W Yum; Chrystalle Katte Carreon; Carol C Gregorio
Journal:  Sci Adv       Date:  2019-09-04       Impact factor: 14.136

9.  Oligomerization Affects the Ability of Human Cyclase-Associated Proteins 1 and 2 to Promote Actin Severing by Cofilins.

Authors:  Vedud Purde; Florian Busch; Elena Kudryashova; Vicki H Wysocki; Dmitri S Kudryashov
Journal:  Int J Mol Sci       Date:  2019-11-12       Impact factor: 5.923

10.  Mechanism of synergistic actin filament pointed end depolymerization by cyclase-associated protein and cofilin.

Authors:  Tommi Kotila; Hugo Wioland; Giray Enkavi; Konstantin Kogan; Ilpo Vattulainen; Antoine Jégou; Guillaume Romet-Lemonne; Pekka Lappalainen
Journal:  Nat Commun       Date:  2019-11-22       Impact factor: 14.919
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