Literature DB >> 3426618

Molecular cloning, cDNA structure and deduced amino acid sequence for a type I regulatory subunit of cAMP-dependent protein kinase from human testis.

M Sandberg1, K Taskén, O Oyen, V Hansson, T Jahnsen.   

Abstract

A 1.5 kilobase (kb) cDNA clone containing the entire coding region for a regulatory subunit of type I cAMP-dependent protein kinase (RI) was isolated from a human testis cDNA library. The cDNA clone encodes a protein of 381 amino acids that shows 98% and 97% homology to the bovine skeletal muscle RI and rat brain RI, respectively. Northern blot analysis demonstrates two major mRNA-species (1.5 and 3.0 kb) in human testis and one mRNA-species (3.0 kb) in human T-lymphocytes.

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Year:  1987        PMID： 3426618     DOI： 10.1016/0006-291x(87)90499-2

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  8 in total

1.  Ala99ser mutation in RI alpha regulatory subunit of protein kinase A causes reduced kinase activation by cAMP and arrest of hormone-dependent breast cancer cell growth.

Authors:  G R Lee; S N Kim; K Noguchi; S D Park; S H Hong; Y S Cho-Chung
Journal:  Mol Cell Biochem       Date:  1999-05       Impact factor: 3.396

2.  An antisense oligodeoxynucleotide targeted against the type II beta regulatory subunit mRNA of protein kinase inhibits cAMP-induced differentiation in HL-60 leukemia cells without affecting phorbol ester effects.

Authors:  G Tortora; T Clair; Y S Cho-Chung
Journal:  Proc Natl Acad Sci U S A       Date:  1990-01       Impact factor: 11.205

3.  Expression of Chinese hamster cAMP-dependent protein kinase in Escherichia coli results in growth inhibition of bacterial cells: a model system for the rapid screening of mutant type I regulatory subunits.

Authors:  M E Gosse; A Padmanabhan; R D Fleischmann; M M Gottesman
Journal:  Proc Natl Acad Sci U S A       Date:  1993-09-01       Impact factor: 11.205

4.  Phosphorylation of the regulatory subunit of type II beta cAMP-dependent protein kinase by cyclin B/p34cdc2 kinase impairs its binding to microtubule-associated protein 2.

Authors:  G Keryer; Z Luo; J C Cavadore; J Erlichman; M Bornens
Journal:  Proc Natl Acad Sci U S A       Date:  1993-06-15       Impact factor: 11.205

5.  Differentiation of HL-60 leukemia by type I regulatory subunit antisense oligodeoxynucleotide of cAMP-dependent protein kinase.

Authors:  G Tortora; H Yokozaki; S Pepe; T Clair; Y S Cho-Chung
Journal:  Proc Natl Acad Sci U S A       Date:  1991-03-01       Impact factor: 11.205

6.  Bacterial expression of Chinese hamster regulatory type-I and catalytic subunits of cyclic AMP-dependent protein kinase and mutational analysis of the type-I regulatory subunit.

Authors:  M E Gosse; R Fleischmann; M Marshall; N Wang; S Garges; M M Gottesman
Journal:  Biochem J       Date:  1994-01-01       Impact factor: 3.857

7.  Expression of protein kinase A and protein kinase C during ongoing human cytomegalovirus infection.

Authors:  A K Kristoffersen; K Taskèn; H Rollag
Journal:  Arch Virol       Date:  1994       Impact factor: 2.574

8.  Differential expression and subcellular localization for subunits of cAMP-dependent protein kinase during ram spermatogenesis.

Authors:  C Pariset; J Feinberg; J L Dacheux; O Oyen; T Jahnsen; S Weinman
Journal:  J Cell Biol       Date:  1989-09       Impact factor: 10.539
  8 in total

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