Literature DB >> 3426599

Translocation of phospholipase A2 from cytosol to membranes induced by 1-oleoyl-2-acetyl-glycerol in serum-free cultured macrophages.

T Schonhardt1, E Ferber.   

Abstract

Macrophages exhibit high activities of a phospholipase A2 which preferentially cleaves arachidonic acid (I. Flesch, B. Schmidt, and E. Ferber, Z. Naturforsch. 40c, 356-363, 1985). In unstimulated cells more than 90% of the total activity of this enzyme is localized in the cytosol. Treatment of these cells with 100 microM 1-oleoyl-2-acetyl-glycerol (OAG) for 30 min induced a translocation of phospholipase A2 to cellular membranes. The amount of translocated phospholipase A2 was about 30% of the total activity and correlated with a similar translocation of protein kinase C to membranes. These data suggest that the translocation of phospholipase A2 to membranes is related to the activation process of this enzyme.

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Year:  1987        PMID： 3426599     DOI： 10.1016/0006-291x(87)90434-7

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  10 in total

1.  Involvement of cytosolic phospholipase A2, and the subsequent release of arachidonic acid, in signalling by rac for the generation of intracellular reactive oxygen species in rat-2 fibroblasts.

Authors:  C H Woo; Z W Lee; B C Kim; K S Ha; J H Kim
Journal:  Biochem J       Date:  2000-06-15       Impact factor: 3.857

2.  Translocation to rat liver mitochondria of phosphatidate phosphohydrolase.

Authors:  M Freeman; E H Mangiapane
Journal:  Biochem J       Date:  1989-10-15       Impact factor: 3.857

Review 3.  Phospholipases and acyltransferases in macrophages.

Authors:  I Flesch; T Schonhardt; E Ferber
Journal:  Klin Wochenschr       Date:  1989-02-01

4.  Implication of the small GTPase Rac1 in the generation of reactive oxygen species in response to beta-amyloid in C6 astroglioma cells.

Authors:  Mina Lee; Hye-Jin You; Sung-Hoon Cho; Chang-Hoon Woo; Min-Hyuk Yoo; Eun-Hye Joe; Jae-Hong Kim
Journal:  Biochem J       Date:  2002-09-15       Impact factor: 3.857

5.  Reactive oxygen species mediate phorbol ester-regulated tyrosine phosphorylation and phospholipase A2 activation: potentiation by vanadate.

Authors:  U Zor; E Ferber; P Gergely; K Szücs; V Dombrádi; R Goldman
Journal:  Biochem J       Date:  1993-11-01       Impact factor: 3.857

Review 6.  12-lipoxygenases and 12(S)-HETE: role in cancer metastasis.

Authors:  K V Honn; D G Tang; X Gao; I A Butovich; B Liu; J Timar; W Hagmann
Journal:  Cancer Metastasis Rev       Date:  1994-12       Impact factor: 9.264

7.  Diradylglycerols stimulate phospholipase A2 and subsequent exocytosis in ram spermatozoa. Evidence that the effect is not mediated via protein kinase C.

Authors:  E R Roldan; C Fragio
Journal:  Biochem J       Date:  1994-01-01       Impact factor: 3.857

8.  Inhibition of calcium-independent phospholipase A2 prevents arachidonic acid incorporation and phospholipid remodeling in P388D1 macrophages.

Authors:  J Balsinde; I D Bianco; E J Ackermann; K Conde-Frieboes; E A Dennis
Journal:  Proc Natl Acad Sci U S A       Date:  1995-08-29       Impact factor: 11.205

9.  Modulation of phospholipase A2 activity by epidermal growth factor (EGF) in CHO cells transfected with human EGF receptor. Role of receptor cytoplasmic subdomain.

Authors:  S Clark; M Dunlop
Journal:  Biochem J       Date:  1991-03-15       Impact factor: 3.857

10.  Cell proliferation status, cytokine action and protein tyrosine phosphorylation modulate leukotriene biosynthesis in a basophil leukaemia and a mastocytoma cell line.

Authors:  W Hagmann
Journal:  Biochem J       Date:  1994-04-15       Impact factor: 3.857
  10 in total

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