Literature DB >> 3426527

The activity of xanthine oxidase in heart of pigs, guinea pigs, rabbits, rats, and humans.

M Muxfeldt1, W Schaper.   

Abstract

We isolated and purified xanthine oxidase by Sephadex gel filtration and assayed the activity of the enzyme by urate production which we measured by HPLC and UV absorption at 290 nm. We applied this method to extracts of liver and heart of rats, guinea pigs, rabbits, and pigs and to heart of dogs and humans. We found that pig hearts do not exhibit xanthine oxidase activity and that human and rabbit hearts produced small amounts of urate only after hours of incubation. We conclude that xanthine oxidase does probably not play an important part in the mechanisms leading to myocardial infarction using the free radical generating pathway, because it is absent in one species (pig) and barely detectable in two others (rabbit and man) that are known for their rapid and complete infarction following acute coronary occlusion.

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Year:  1987        PMID： 3426527     DOI： 10.1007/BF01907096

Source DB:  PubMed          Journal:  Basic Res Cardiol        ISSN： 0300-8428            Impact factor:   17.165


  32 in total

1.  Superoxide-dependent production of hydroxyl radical catalyzed by iron-EDTA complex.

Authors:  J M McCord; E D Day
Journal:  FEBS Lett       Date:  1978-02-01       Impact factor: 4.124

Review 2.  Xanthine oxidase: biochemistry, distribution and physiology.

Authors:  D A Parks; D N Granger
Journal:  Acta Physiol Scand Suppl       Date:  1986

3.  Effects of allopurinol on purine metabolism in cultured heart cells.

Authors:  E Kmetec; A R Mendoza; E L Stanley
Journal:  Biochem Pharmacol       Date:  1978       Impact factor: 5.858

4.  A comparison of the distribution and electron acceptor specificities of xanthine oxidase and aldehyde oxidase.

Authors:  T A Krenitsky; J V Tuttle; E L Cattau; P Wang
Journal:  Comp Biochem Physiol B       Date:  1974-12-15

5.  Xanthine oxidase as a source of free radical damage in myocardial ischemia.

Authors:  D E Chambers; D A Parks; G Patterson; R Roy; J M McCord; S Yoshida; L F Parmley; J M Downey
Journal:  J Mol Cell Cardiol       Date:  1985-02       Impact factor: 5.000

6.  Influence of collateral blood flow and of variations in MVO2 on tissue-ATP content in ischemic and infarcted myocardium.

Authors:  W Schaper; K Binz; S Sass; B Winkler
Journal:  J Mol Cell Cardiol       Date:  1987-01       Impact factor: 5.000

7.  Involvement of hydrogen peroxide and hydroxyl radical in the 'oxygen paradox': reduction of creatine kinase release by catalase, allopurinol or deferoxamine, but not by superoxide dismutase.

Authors:  C L Myers; S J Weiss; M M Kirsh; M Shlafer
Journal:  J Mol Cell Cardiol       Date:  1985-07       Impact factor: 5.000

8.  Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer: a hypothesis.

Authors:  B N Ames; R Cathcart; E Schwiers; P Hochstein
Journal:  Proc Natl Acad Sci U S A       Date:  1981-11       Impact factor: 11.205

9.  The role of lipid peroxidation in pathogenesis of ischemic damage and the antioxidant protection of the heart.

Authors:  F Z Meerson; V E Kagan; L M Belkina
Journal:  Basic Res Cardiol       Date:  1982 Sep-Oct       Impact factor: 17.165

10.  Xanthine oxidase type D (dehydrogenase) in the intestine and other organs of the rat.

Authors:  M G Battelli; E Della Corte; F Stirpe
Journal:  Biochem J       Date:  1972-02       Impact factor: 3.766
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  27 in total

1.  Reperfusion Injury: An Opinionated View.

Authors: 
Journal:  J Thromb Thrombolysis       Date:  1997-01       Impact factor: 2.300

2.  Intracoronary infusion of superoxide dismutase and reperfusion injury in the pig heart.

Authors:  D Garcia-Dorado; P Théroux; J Alonso; J Elizaga; J Botas; F Fernandez-Avilés; J Soriano; R Munoz; J Solares
Journal:  Basic Res Cardiol       Date:  1990 Nov-Dec       Impact factor: 17.165

Review 3.  Molecular mechanisms in "stunned" myocardium.

Authors:  W Schaper
Journal:  Cardiovasc Drugs Ther       Date:  1991-10       Impact factor: 3.727

4.  Beneficial effect of beraprost, a prostacyclin-mimetic agent, on post-hypoxic recovery of cardiac function and metabolism in rabbit isolated hearts.

Authors:  K Tanonaka; Y Maruyama; S Takeo
Journal:  Br J Pharmacol       Date:  1991-12       Impact factor: 8.739

5.  Lipid peroxidation during myocardial ischaemia induced by pacing.

Authors:  K G Oldroyd; M Chopra; A C Rankin; J J Belch; S M Cobbe
Journal:  Br Heart J       Date:  1990-02

6.  Relationship between free radicals and adenosine in the mechanism of preconditioning: are they interrelated or independent triggers?

Authors:  T Fukuma; T Miura; K Suzuki; A Tsuchida; Y Nozawa; K Shimamoto
Journal:  Mol Cell Biochem       Date:  2000-08       Impact factor: 3.396

7.  Ischemic heart diseases in Egypt: role of xanthine oxidase system and ischemia-modified albumin.

Authors:  Ola Sayed Ali; Hanan Muhammad Abdelgawad; Makram Sayed Mohammed; Rehab Refaat El-Awady
Journal:  Heart Vessels       Date:  2013-10-04       Impact factor: 2.037

8.  Allopurinol-enhanced myocardial protection does not involve xanthine oxidase inhibition or purine salvage.

Authors:  D J Chambers; A Takahashi; S M Humphrey; D M Harvey; D J Hearse
Journal:  Basic Res Cardiol       Date:  1992 May-Jun       Impact factor: 17.165

9.  Impaired endothelium-dependent relaxation of dog coronary arteries after myocardial ischaemia and reperfusion: prevention by amlodipine, propranolol and allopurinol.

Authors:  C G Sobey; R A Dalipram; G J Dusting; O L Woodman
Journal:  Br J Pharmacol       Date:  1992-03       Impact factor: 8.739

10.  Nitric oxide production from nitrite occurs primarily in tissues not in the blood: critical role of xanthine oxidase and aldehyde oxidase.

Authors:  Haitao Li; Hongmei Cui; Tapan Kumar Kundu; Wael Alzawahra; Jay L Zweier
Journal:  J Biol Chem       Date:  2008-04-18       Impact factor: 5.157
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