Literature DB >> 34265210

Prostaglandin I2 and T Regulatory Cell Function: Broader Impacts.

Allison E Norlander1, R Stokes Peebles1,2,3.   

Abstract

Tregulatory cells (Tregs) are an important member of the adaptive immune system and function to reduce and resolve inflammation. Prostaglandin I2 (PGI2) is a lipid mediator that has potent anti-inflammatory effects on immune cells. Several studies have investigated the interplay between PGI2 and Tregs. Together, the data from these studies demonstrate that PGI2 promotes the formation and function of Tregs. This suggests that therapeutic supplementation of PGI2 may be a treatment for various autoimmune or inflammatory diseases through enhancement of Treg function.

Entities:  

Keywords:  Treg; immunology; inflammation

Mesh：

Substances：

Year:  2021        PMID： 34265210      PMCID： PMC8818510          DOI： 10.1089/dna.2021.0515

Source DB:  PubMed          Journal:  DNA Cell Biol        ISSN： 1044-5498            Impact factor:   3.550


  31 in total

1.  Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression.

Authors:  Yisong Y Wan; Richard A Flavell
Journal:  Nature       Date:  2007-01-14       Impact factor: 49.962

Review 2.  Dendritic cell subsets in T cell programming: location dictates function.

Authors:  S C Eisenbarth
Journal:  Nat Rev Immunol       Date:  2019-02       Impact factor: 53.106

3.  Cyclooxygenase inhibition abrogates aeroallergen-induced immune tolerance by suppressing prostaglandin I2 receptor signaling.

Authors:  Weisong Zhou; Kasia Goleniewska; Jian Zhang; Daniel E Dulek; Shinji Toki; Matthew T Lotz; Dawn C Newcomb; Madison G Boswell; Vasiliy V Polosukhin; Ginger L Milne; Pingsheng Wu; Martin L Moore; Garret A FitzGerald; R Stokes Peebles
Journal:  J Allergy Clin Immunol       Date:  2014-07-18       Impact factor: 10.793

4.  Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse.

Authors:  M E Brunkow; E W Jeffery; K A Hjerrild; B Paeper; L B Clark; S A Yasayko; J E Wilkinson; D Galas; S F Ziegler; F Ramsdell
Journal:  Nat Genet       Date:  2001-01       Impact factor: 38.330

Review 5.  tTregs, pTregs, and iTregs: similarities and differences.

Authors:  Ethan M Shevach; Angela M Thornton
Journal:  Immunol Rev       Date:  2014-05       Impact factor: 12.988

6.  Dominant Role for Regulatory T Cells in Protecting Females Against Pulmonary Hypertension.

Authors:  Rasa Tamosiuniene; Olga Manouvakhova; Paul Mesange; Toshie Saito; Jin Qian; Mrinmoy Sanyal; Yu-Chun Lin; Linh P Nguyen; Amir Luria; Allen B Tu; Joshua M Sante; Marlene Rabinovitch; Desmond J Fitzgerald; Brian B Graham; Aida Habtezion; Norbert F Voelkel; Laure Aurelian; Mark R Nicolls
Journal:  Circ Res       Date:  2018-03-15       Impact factor: 17.367

7.  An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation.

Authors:  S Moncada; R Gryglewski; S Bunting; J R Vane
Journal:  Nature       Date:  1976-10-21       Impact factor: 49.962

8.  Prostaglandin I2-IP signaling blocks allergic pulmonary inflammation by preventing recruitment of CD4+ Th2 cells into the airways in a mouse model of asthma.

Authors:  Zeina Jaffar; Maria E Ferrini; Mary C Buford; Garret A Fitzgerald; Kevan Roberts
Journal:  J Immunol       Date:  2007-11-01       Impact factor: 5.422

9.  X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy.

Authors:  R S Wildin; F Ramsdell; J Peake; F Faravelli; J L Casanova; N Buist; E Levy-Lahad; M Mazzella; O Goulet; L Perroni; F D Bricarelli; G Byrne; M McEuen; S Proll; M Appleby; M E Brunkow
Journal:  Nat Genet       Date:  2001-01       Impact factor: 38.330

10.  Genetic and epigenetic studies of FOXP3 in asthma and allergy.

Authors:  Cintia Rodrigues Marques; Ryan Santos Costa; Gustavo Nunes de Oliveira Costa; Thiago Magalhães da Silva; Tatiane Oliveira Teixeira; Emília Maria Medeiros de Andrade; Alana A Galvão; Valdirene Leão Carneiro; Camila Alexandrina Figueiredo
Journal:  Asthma Res Pract       Date:  2015-10-20
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