Ana Luiza Zaninotto1,2, Daphine Centola Grassi3,4, Dante Duarte5, Priscila Aparecida Rodrigues6, Ellison Cardoso3,4, Fabricio Stewan Feltrin3,4,7, Vinicius Monteiro de Paula Guirado6, Fabiola Bezerra de Carvalho Macruz3,4, Maria Concepción Garcia Otaduy3,4, Claudia da Costa Leite3,4, Wellingson Silva Paiva6, Celi Santos Andrade3,4. 1. Speech and Feeding Disorders Lab, MGH Institute of Health Professions (MGHIHP), Boston, MA, USA. acostazaninotto@mghihp.edu. 2. Department of Neurology, School of Medicine, University São Paulo (USP-SP), São Paulo, SP, Brazil. acostazaninotto@mghihp.edu. 3. Laboratory of Medical Investigation, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil. 4. Department of Radiology, Faculdade de Medicina da Universidade de São Paulo, LIM 44 -HCFMUSP, São Paulo, Brazil. 5. Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada. 6. Department of Neurology, School of Medicine, University São Paulo (USP-SP), São Paulo, SP, Brazil. 7. Radiology Department, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Abstract
BACKGROUND AND AIM: Diffusion tensor imaging (DTI) parameters in the corpus callosum have been suggested to be a biomarker for prognostic outcomes in individuals with diffuse axonal injury (DAI). However, differences between the DTI parameters on moderate and severe trauma in DAI over time are still unclear. A secondary goal was to study the association between the changes in the DTI parameters, anxiety, and depressive scores in DAI over time. METHODS: Twenty subjects were recruited from a neurological outpatient clinic and evaluated at 2, 6, and 12 months after the brain injury and compared to matched age and sex healthy controls regarding the DTI parameters in the corpus callosum. State-Trace Anxiety Inventory and Beck Depression Inventory were used to assess psychiatric outcomes in the TBI group over time. RESULTS: Differences were observed in the fractional anisotropy and mean diffusivity of the genu, body, and splenium of the corpus callosum between DAI and controls (p < 0.02). Differences in both parameters in the genu of the corpus callosum were also detected between patients with moderate and severe DAI (p < 0.05). There was an increase in the mean diffusivity values and the fractional anisotropy decrease in the DAI group over time (p < 0.02). There was no significant correlation between changes in the fractional anisotropy and mean diffusivity across the study and psychiatric outcomes in DAI. CONCLUSION: DTI parameters, specifically the mean diffusivity in the corpus callosum, may provide reliable characterization and quantification of differences determined by the brain injury severity. No correlation was observed with DAI parameters and the psychiatric outcome scores.
BACKGROUND AND AIM: Diffusion tensor imaging (DTI) parameters in the corpus callosum have been suggested to be a biomarker for prognostic outcomes in individuals with diffuse axonal injury (DAI). However, differences between the DTI parameters on moderate and severe trauma in DAI over time are still unclear. A secondary goal was to study the association between the changes in the DTI parameters, anxiety, and depressive scores in DAI over time. METHODS: Twenty subjects were recruited from a neurological outpatient clinic and evaluated at 2, 6, and 12 months after the brain injury and compared to matched age and sex healthy controls regarding the DTI parameters in the corpus callosum. State-Trace Anxiety Inventory and Beck Depression Inventory were used to assess psychiatric outcomes in the TBI group over time. RESULTS: Differences were observed in the fractional anisotropy and mean diffusivity of the genu, body, and splenium of the corpus callosum between DAI and controls (p < 0.02). Differences in both parameters in the genu of the corpus callosum were also detected between patients with moderate and severe DAI (p < 0.05). There was an increase in the mean diffusivity values and the fractional anisotropy decrease in the DAI group over time (p < 0.02). There was no significant correlation between changes in the fractional anisotropy and mean diffusivity across the study and psychiatric outcomes in DAI. CONCLUSION: DTI parameters, specifically the mean diffusivity in the corpus callosum, may provide reliable characterization and quantification of differences determined by the brain injury severity. No correlation was observed with DAI parameters and the psychiatric outcome scores.
Authors: Annette Sidaros; Aase W Engberg; Karam Sidaros; Matthew G Liptrot; Margrethe Herning; Palle Petersen; Olaf B Paulson; Terry L Jernigan; Egill Rostrup Journal: Brain Date: 2007-12-14 Impact factor: 13.501
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