Literature DB >> 34262062

Disorder predispositions and protections of Labrador Retrievers in the UK.

Camilla Pegram1, Charlotte Woolley2, Dave C Brodbelt3, David B Church4, Dan G O'Neill3.   

Abstract

The Labrador Retriever is one of the most popular dog breeds worldwide, therefore it is important to have reliable evidence on the general health issues of the breed. Using anonymised veterinary clinical data from the VetCompass Programme, this study aimed to explore the relative risk to common disorders in the Labrador Retriever. The clinical records of a random sample of dogs were reviewed to extract the most definitive diagnoses for all disorders recorded during 2016. A list of disorders was generated, including the 30 most common disorders in Labrador Retrievers and the 30 most common disorders in non-Labrador Retrievers. Multivariable logistic regression was used to report the odds of each of these disorders in 1462 (6.6%) Labrador Retrievers compared with 20,786 (93.4%) non-Labrador Retrievers. At a specific-level of diagnostic precision, after accounting for confounding, Labrador Retrievers had significantly increased odds of 12/35 (34.3%) disorders compared to non-Labrador Retrievers; osteoarthritis (OR 2.83) had the highest odds. Conversely, Labrador Retrievers had reduced odds of 7/35 (20.0%) disorders; patellar luxation (OR 0.18) had the lowest odds. This study provides useful information about breed-specific disorder predispositions and protections, which future research could evaluate further to produce definitive guidance for Labrador Retriever breeders and owners.
© 2021. The Author(s).

Entities:  

Year:  2021        PMID: 34262062     DOI: 10.1038/s41598-021-93379-2

Source DB:  PubMed          Journal:  Sci Rep        ISSN: 2045-2322            Impact factor:   4.379


  64 in total

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Journal:  Genomics       Date:  2006-08-30       Impact factor: 5.736

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Journal:  Vet J       Date:  2017-07-29       Impact factor: 2.688

3.  MTM1 mutation associated with X-linked myotubular myopathy in Labrador Retrievers.

Authors:  Alan H Beggs; Johann Böhm; Elizabeth Snead; Marek Kozlowski; Marie Maurer; Katie Minor; Martin K Childers; Susan M Taylor; Christophe Hitte; James R Mickelson; Ling T Guo; Andrew P Mizisin; Anna Buj-Bello; Laurent Tiret; Jocelyn Laporte; G Diane Shelton
Journal:  Proc Natl Acad Sci U S A       Date:  2010-08-03       Impact factor: 11.205

4.  Estimation of population divergence times from non-overlapping genomic sequences: examples from dogs and wolves.

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Journal:  Mol Biol Evol       Date:  2010-12-21       Impact factor: 16.240

5.  Incidence of the mask phenotype M264V mutation in Labrador Retrievers.

Authors:  E K Conant; R Juras; E G Cothran
Journal:  Res Vet Sci       Date:  2011-02-24       Impact factor: 2.534

Review 6.  The domestic dog: man's best friend in the genomic era.

Authors:  Adam R Boyko
Journal:  Genome Biol       Date:  2011-02-22       Impact factor: 13.583

7.  The challenges of pedigree dog health: approaches to combating inherited disease.

Authors:  Lindsay L Farrell; Jeffrey J Schoenebeck; Pamela Wiener; Dylan N Clements; Kim M Summers
Journal:  Canine Genet Epidemiol       Date:  2015-02-11

8.  A Deletion in the Canine POMC Gene Is Associated with Weight and Appetite in Obesity-Prone Labrador Retriever Dogs.

Authors:  Eleanor Raffan; Rowena J Dennis; Conor J O'Donovan; Julia M Becker; Robert A Scott; Stephen P Smith; David J Withers; Claire J Wood; Elena Conci; Dylan N Clements; Kim M Summers; Alexander J German; Cathryn S Mellersh; Maja L Arendt; Valentine P Iyemere; Elaine Withers; Josefin Söder; Sara Wernersson; Göran Andersson; Kerstin Lindblad-Toh; Giles S H Yeo; Stephen O'Rahilly
Journal:  Cell Metab       Date:  2016-05-03       Impact factor: 27.287

9.  mtDNA data indicate a single origin for dogs south of Yangtze River, less than 16,300 years ago, from numerous wolves.

Authors:  Jun-Feng Pang; Cornelya Kluetsch; Xiao-Ju Zou; Ai-bing Zhang; Li-Yang Luo; Helen Angleby; Arman Ardalan; Camilla Ekström; Anna Sköllermo; Joakim Lundeberg; Shuichi Matsumura; Thomas Leitner; Ya-Ping Zhang; Peter Savolainen
Journal:  Mol Biol Evol       Date:  2009-09-01       Impact factor: 16.240

10.  The Menkes and Wilson disease genes counteract in copper toxicosis in Labrador retrievers: a new canine model for copper-metabolism disorders.

Authors:  Hille Fieten; Yadvinder Gill; Alan J Martin; Mafalda Concilli; Karen Dirksen; Frank G van Steenbeek; Bart Spee; Ted S G A M van den Ingh; Ellen C C P Martens; Paola Festa; Giancarlo Chesi; Bart van de Sluis; Roderick H J H Houwen; Adrian L Watson; Yurii S Aulchenko; Victoria L Hodgkinson; Sha Zhu; Michael J Petris; Roman S Polishchuk; Peter A J Leegwater; Jan Rothuizen
Journal:  Dis Model Mech       Date:  2016-01       Impact factor: 5.758

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  4 in total

1.  English Bulldogs in the UK: a VetCompass study of their disorder predispositions and protections.

Authors:  Dan G O'Neill; Alison Skipper; Rowena M A Packer; Caitriona Lacey; Dave C Brodbelt; David B Church; Camilla Pegram
Journal:  Canine Med Genet       Date:  2022-06-15

2.  Health of Pug dogs in the UK: disorder predispositions and protections.

Authors:  Dan G O'Neill; Jaya Sahota; Dave C Brodbelt; David B Church; Rowena M A Packer; Camilla Pegram
Journal:  Canine Med Genet       Date:  2022-05-18

3.  French Bulldogs differ to other dogs in the UK in propensity for many common disorders: a VetCompass study.

Authors:  Dan G O'Neill; Rowena M A Packer; Peter Francis; David B Church; Dave C Brodbelt; Camilla Pegram
Journal:  Canine Med Genet       Date:  2021-12-16

4.  Frequency, breed predispositions and other demographic risk factors for diagnosis of hypothyroidism in dogs under primary veterinary care in the UK.

Authors:  Dan G O'Neill; Janine Su Pheng Khoo; Dave C Brodbelt; David B Church; Camilla Pegram; Rebecca F Geddes
Journal:  Canine Med Genet       Date:  2022-10-10
  4 in total

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