| Literature DB >> 34260717 |
Isabella Ferreira1,2, Steven Kemp1,2, Rawlings Datir1,2, Akatsuki Saito3, Bo Meng1,2, Partha Rakshit4, Akifumi Takaori-Kondo5, Yusuke Kosugi6, Keiya Uriu6, Izumi Kimura6, Kotaro Shirakawa6, Adam Abdullahi1,2, Anurag Agarwal7, Seiya Ozono8, Kenzo Tokunaga8, Kei Sato6,9, Ravindra K Gupta1,2,10.
Abstract
The SARS-CoV-2 B.1.617 variant emerged in the Indian state of Maharashtra in late 2020. There have been fears that two key mutations seen in the receptor binding domain L452R and E484Q would have additive effects on evasion of neutralising antibodies. We report that spike bearing L452R and E484Q confers modestly reduced sensitivity to BNT162b2 mRNA vaccine-elicited antibodies following either first or second dose. The effect is similar in magnitude to the loss of sensitivity conferred by L452R or E484Q alone. These data demonstrate reduced sensitivity to vaccine elicited neutralising antibodies by L452R and E484Q but lack of synergistic loss of sensitivity.Entities:
Keywords: B.1.617; COVID-19; Indian variant; SARS-CoV-2; antibody escape; evasion; fitness; infectivity; neutralising antibodies; resistance; spike mutation
Year: 2021 PMID： 34260717 DOI： 10.1093/infdis/jiab368
Source DB: PubMed Journal: J Infect Dis ISSN： 0022-1899 Impact factor: 5.226