Eleni Karakike1, Evangelos J Giamarellos-Bourboulis, Miltiades Kyprianou, Carolin Fleischmann-Struzek, Mathias W Pletz, Mihai G Netea, Konrad Reinhart, Evdoxia Kyriazopoulou. 1. 4th Department of Internal Medicine, National and Kapodistrian University of Athens, Medical School, Athens, Greece. Institute for Infectious Diseases and Infection Control, Jena University Hospital, Jena, Germany. Center for Sepsis Control and Care, Jena University Hospital, Jena, Germany. Department of Internal Medicine and Center for Infectious Diseases, Radboud University, Nijmegen, The Netherlands. Department of Immunology and Metabolism, Life & Medical Sciences Institute, University of Bonn, Bonn, Germany. Department of Anesthesiology and Operative Intensive Care Medicine (CCM, CVK), Charité Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Berlin, Germany.
Abstract
OBJECTIVE: Coronavirus disease 2019 is a heterogeneous disease most frequently causing respiratory tract infection, which can induce respiratory failure and multiple organ dysfunction syndrome in its severe forms. The prevalence of coronavirus disease 2019-related sepsis is still unclear; we aimed to describe this in a systematic review. DATA SOURCES: MEDLINE (PubMed), Cochrane, and Google Scholar databases were searched based on a prespecified protocol (International Prospective Register for Systematic Reviews: CRD42020202018). STUDY SELECTION: Studies reporting on patients with confirmed coronavirus disease 2019 diagnosed with sepsis according to sepsis-3 or according to the presence of infection-related organ dysfunctions necessitating organ support/replacement were included in the analysis. The primary end point was prevalence of coronavirus disease 2019-related sepsis among adults hospitalized in the ICU and the general ward. Among secondary end points were the need for ICU admission among patients initially hospitalized in the general ward and the prevalence of new onset of organ dysfunction in the ICU. Outcomes were expressed as proportions with respective 95% CI. DATA EXTRACTION: Two reviewers independently screened and reviewed existing literature and assessed study quality with the Newcastle-Ottawa Scale and the Methodological index for nonrandomized studies. DATA SYNTHESIS: Of 3,825 articles, 151 were analyzed, only five of which directly reported sepsis prevalence. Noting the high heterogeneity observed, coronavirus disease 2019-related sepsis prevalence was 77.9% (95% CI, 75.9-79.8; I2 = 91%; 57 studies) in the ICU, and 33.3% (95% CI, 30.3-36.4; I2 = 99%; 86 studies) in the general ward. ICU admission was required for 17.7% (95% CI, 12.9-23.6; I2 = 100%) of ward patients. Acute respiratory distress syndrome was the most common organ dysfunction in the ICU (87.5%; 95% CI, 83.3-90.7; I2 = 98%). CONCLUSIONS: The majority of coronavirus disease 2019 patients hospitalized in the ICU meet Sepsis-3 criteria and present infection-associated organ dysfunction. The medical and scientific community should be aware and systematically report viral sepsis for prognostic and treatment implications.
OBJECTIVE:Coronavirus disease 2019 is a heterogeneous disease most frequently causing respiratory tract infection, which can induce respiratory failure and multiple organ dysfunction syndrome in its severe forms. The prevalence of coronavirus disease 2019-related sepsis is still unclear; we aimed to describe this in a systematic review. DATA SOURCES: MEDLINE (PubMed), Cochrane, and Google Scholar databases were searched based on a prespecified protocol (International Prospective Register for Systematic Reviews: CRD42020202018). STUDY SELECTION: Studies reporting on patients with confirmed coronavirus disease 2019 diagnosed with sepsis according to sepsis-3 or according to the presence of infection-related organ dysfunctions necessitating organ support/replacement were included in the analysis. The primary end point was prevalence of coronavirus disease 2019-related sepsis among adults hospitalized in the ICU and the general ward. Among secondary end points were the need for ICU admission among patients initially hospitalized in the general ward and the prevalence of new onset of organ dysfunction in the ICU. Outcomes were expressed as proportions with respective 95% CI. DATA EXTRACTION: Two reviewers independently screened and reviewed existing literature and assessed study quality with the Newcastle-Ottawa Scale and the Methodological index for nonrandomized studies. DATA SYNTHESIS: Of 3,825 articles, 151 were analyzed, only five of which directly reported sepsis prevalence. Noting the high heterogeneity observed, coronavirus disease 2019-related sepsis prevalence was 77.9% (95% CI, 75.9-79.8; I2 = 91%; 57 studies) in the ICU, and 33.3% (95% CI, 30.3-36.4; I2 = 99%; 86 studies) in the general ward. ICU admission was required for 17.7% (95% CI, 12.9-23.6; I2 = 100%) of ward patients. Acute respiratory distress syndrome was the most common organ dysfunction in the ICU (87.5%; 95% CI, 83.3-90.7; I2 = 98%). CONCLUSIONS: The majority of coronavirus disease 2019patients hospitalized in the ICU meet Sepsis-3 criteria and present infection-associated organ dysfunction. The medical and scientific community should be aware and systematically report viral sepsis for prognostic and treatment implications.
Authors: Daniel G Camblor; Daniel Miranda; Guillermo M Albaiceta; Laura Amado-Rodríguez; Elías Cuesta-Llavona; Daniel Vázquez-Coto; Julia Gómez de Oña; Claudia García-Lago; Juan Gómez; Eliecer Coto Journal: Hum Immunol Date: 2022-06-21 Impact factor: 2.211
Authors: Raquel Almansa; Jose María Eiros; David de Gonzalo-Calvo; Tamara Postigo; Alicia Ortega; Raul Lopez-Izquierdo; Anna Moncusí-Moix; Clara Gort-Paniello; Marta Dominguez-Gil; Amanda de la Fuente; Laura González-González; Tania Luis-García; Nadia García-Mateo; Ana P Tedim; Fátima Rodríguez-Jara; Noelia Jorge; Jessica González; Gerard Torres; Oliver Norberto Gutiérrez-Pérez; Maria José Villegas; Sonia Campo; Eva Ayllon; Tomás Ruiz Albi; Julio de Frutos Arribas; Ainhoa Arroyo Domingo; Jesica Abadia-Otero; Julia Gómez Barquero; Wysali Trapiello; Luis Javier Garcia Frade; Luis Inglada; Felix Del Campo; Jesús F Bermejo-Martin; Ferran Barbé; Antoni Torres Journal: Clin Microbiol Infect Date: 2022-05-30 Impact factor: 13.310