Seyed Alireza Javadinia1, Nooshin Nazeminezhad2, Ruhollah Ghahramani-Asl1, Davood Soroosh1, Danial Fazilat-Panah3, Babak PeyroShabany4, Seyedeh Naeimeh Saberhosseini5, Arezoo Mehrabian6, Farzad Taghizadeh-Hesary7, Mohammad Nematshahi8, Gaurav Dhawan9, James S Welsh10, Edward J Calabrese11, Rachna Kapoor12. 1. Clinical Research Development Unit, Hospital Research Development Committee, Sabzevar University of Medical Sciences, Sabzevar, Iran. 2. Cancer Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. 3. Cancer Research Center, Babol University of Medical Sciences, Babol, Iran. 4. Department of Internal Medicine, Sabzevar University of Medical Sciences, Sabzevar, Iran. 5. Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran. 6. Research Committee, Iran University of Medical Sciences, Tehran, Iran. 7. Department of Clinical Oncology, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 8. Department of Anesthesiology and Critical Care, Sabzevar University of Medical Sciences, Sabzevar, Iran. 9. Sri Guru Ram Das University of Health Sciences, Amritsar, India. 10. Edward Hines Jr. VA Hospital, Loyola University Chicago Stritch School of Medicine, Chicago, IL, USA. 11. Department of Environmental Health Sciences, School of Public Health and Health Sciences, University of Massachusetts, Amherst, MA, USA. 12. Saint Francis Hospital and Medical Center, Hartford, CT, USA.
Abstract
BACKGROUND: Osteoarthritis (OA), the most common degenerative joint disease, is associated with severe functional limitation and impairment of quality of life. Numerous reports have documented the clinical efficacy of low-dose radiotherapy (LD-RT) in the management of various inflammatory disorders, including OA. In this paper, we assessed the clinical literature involving the use of LD-RT in the treatment of OA, its dose-response features, possible underlying mechanistic features, and optimal therapeutic dose range. METHODS: We carried out a systematic review based on the guidelines of the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) statements and evaluated articles meeting the inclusion criteria for this review. RESULTS: A total of 361 articles were identified from databases, such as Scopus, PubMed, Embase, and Science Direct out of which 224 articles were duplicates and were discarded. Of the remaining 137 articles, 74 articles were un-related, 27 articles were review articles, eight were conference abstracts, three were letters, two were editorials, two were notes, and one was a book chapter. Finally, 20 articles met all the inclusion criteria and were included in this systematic review. DISCUSSION: Several single-arm retrospective/prospective studies showed advantages for LD-RT in the management of OA in terms of pain relief, improvement of mobility and function, and showed minimal side effects. Mechanistic considerations involve positive subcellular effects mediated by the activation of a nuclear factor erythroid 2-related transcription factor (Nrf2) mediated antioxidant response. Further research on both the short- and long-term effects of LD-RT on OA and other inflammatory disorders is recommended.
BACKGROUND: Osteoarthritis (OA), the most common degenerative joint disease, is associated with severe functional limitation and impairment of quality of life. Numerous reports have documented the clinical efficacy of low-dose radiotherapy (LD-RT) in the management of various inflammatory disorders, including OA. In this paper, we assessed the clinical literature involving the use of LD-RT in the treatment of OA, its dose-response features, possible underlying mechanistic features, and optimal therapeutic dose range. METHODS: We carried out a systematic review based on the guidelines of the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) statements and evaluated articles meeting the inclusion criteria for this review. RESULTS: A total of 361 articles were identified from databases, such as Scopus, PubMed, Embase, and Science Direct out of which 224 articles were duplicates and were discarded. Of the remaining 137 articles, 74 articles were un-related, 27 articles were review articles, eight were conference abstracts, three were letters, two were editorials, two were notes, and one was a book chapter. Finally, 20 articles met all the inclusion criteria and were included in this systematic review. DISCUSSION: Several single-arm retrospective/prospective studies showed advantages for LD-RT in the management of OA in terms of pain relief, improvement of mobility and function, and showed minimal side effects. Mechanistic considerations involve positive subcellular effects mediated by the activation of a nuclear factor erythroid 2-related transcription factor (Nrf2) mediated antioxidant response. Further research on both the short- and long-term effects of LD-RT on OA and other inflammatory disorders is recommended.
Authors: Robert Michael Hermann; Annika Trillmann; Jan-Niklas Becker; Alexander Kaltenborn; Mirko Nitsche; Mike Ruettermann Journal: Med Sci (Basel) Date: 2021-10-27
Authors: Thomas Weissmann; Michael Rückert; Jian-Guo Zhou; Michaela Seeling; Sebastian Lettmaier; Anna-Jasmina Donaubauer; Falk Nimmerjahn; Oliver J Ott; Markus Hecht; Florian Putz; Rainer Fietkau; Benjamin Frey; Udo S Gaipl; Lisa Deloch Journal: Front Immunol Date: 2022-01-03 Impact factor: 7.561