Shujing Wu1,2, Zhiyun Zhao1,2, Shanshan Liu1,2, Mian Li1,2, Tiange Wang1,2, Shuangyuan Wang1,2, Min Xu1,2, Yuhong Chen1,2, Meng Dai1,2, Di Zhang1,2, Xuefeng Yu3, Xulei Tang4, Ruying Hu5, Zhen Ye5, Lixin Shi6, Qing Su7, Li Yan8, Guijun Qin9, Qin Wan10, Gang Chen11, Zhengnan Gao12, Guixia Wang13, Feixia Shen14, Zuojie Luo15, Yingfen Qin15, Li Chen16, Yanan Huo17, Qiang Li18, Yinfei Zhang19, Chao Liu20, Youmin Wang21, Shengli Wu22, Tao Yang23, Huacong Deng24, Lulu Chen25, Jiajun Zhao26, Yiming Mu27, Yiping Xu28, Yufang Bi1,2, Jieli Lu1,2, Yu Xu1,2, Weiqing Wang1,2, Guang Ning1,2. 1. Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China. 2. Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China. 3. Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. 4. The First Hospital of Lanzhou University, Lanzhou, China. 5. Zhejiang Provincial Center for Disease Control and Prevention, Zhejiang, China. 6. Affiliated Hospital of Guiyang Medical College, Guiyang, China. 7. Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China. 8. Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China. 9. The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China. 10. The Affiliated Hospital of Luzhou Medical College, Luzhou, China. 11. Fujian Provincial Hospital, Fujian Medical University, Fuzhou, China. 12. Dalian Municipal Central Hospital, Dalian Medical University, Dalian, China. 13. The First Hospital of Jilin University, Changchun, China. 14. The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China. 15. The First Affiliated Hospital of Guangxi Medical University, Nanning, China. 16. Qilu Hospital of Shandong University, Jinan, China. 17. Jiangxi Provincial People's Hospital Affiliated to Nanchang University, Nanchang, China. 18. The Second Affiliated Hospital of Harbin Medical University, Harbin, China. 19. Central Hospital of Shanghai Jiading District, Shanghai, China. 20. Jiangsu Province Hospital on Integration of Chinese and Western Medicine, Nanjing, China. 21. The First Affiliated Hospital of Anhui Medical University, Hefei, China. 22. Karamay Municipal People's Hospital, Xinjiang, China. 23. The First Affiliated Hospital of Nanjing Medical University, Nanjing, China. 24. The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. 25. Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. 26. Shandong Provincial Hospital affiliated to Shandong University, Jinan, China. 27. Chinese People's Liberation Army General Hospital, Beijing, China. 28. Clinical Trials Center, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Abstract
BACKGROUND: Type 2 diabetes is increasingly diagnosed at a younger age worldwide and in China. Limited data are available regarding the association between age at diabetes diagnosis and risks of albuminuria. This study sought to examine the independent effect of age at diagnosis of type 2 diabetes on the risk of albuminuria. METHODS: We used data from a nationwide multicenter study with 207 961 participants in mainland China. Age, sex, and study site were matched for 31 366 screen-detected type 2 diabetes cases and 31 366 normal controls. Age, sex, study site, and diabetes duration were matched for 7490 self-reported type 2 diabetes cases and 7490 normal controls. Risks of having albuminuria in matched type 2 diabetes vs controls were examined using multivariable logistic regression analysis in strata of age at diabetes diagnosis. RESULTS: Although the absolute rate of albuminuria is higher in older adults, the odds ratio of albuminuria in type 2 diabetes vs matched controls decreased with increasing age at diagnosis. For participants with diabetes diagnosed at an age of <50, 50 to 59, 60 to 69, or ≥70 years, the multivariable adjusted risk of albuminuria increased by 81%, 60%, 45%, and 33% for screen-detected diabetes, and 135%, 121%, 90%, and 58% for self-reported diabetes compared with their normal controls, respectively. CONCLUSIONS: A younger age at diagnosis of type 2 diabetes is associated with a more significantly elevated risk of albuminuria than an older age at diagnosis in Chinese adults.
BACKGROUND: Type 2 diabetes is increasingly diagnosed at a younger age worldwide and in China. Limited data are available regarding the association between age at diabetes diagnosis and risks of albuminuria. This study sought to examine the independent effect of age at diagnosis of type 2 diabetes on the risk of albuminuria. METHODS: We used data from a nationwide multicenter study with 207 961 participants in mainland China. Age, sex, and study site were matched for 31 366 screen-detected type 2 diabetes cases and 31 366 normal controls. Age, sex, study site, and diabetes duration were matched for 7490 self-reported type 2 diabetes cases and 7490 normal controls. Risks of having albuminuria in matched type 2 diabetes vs controls were examined using multivariable logistic regression analysis in strata of age at diabetes diagnosis. RESULTS: Although the absolute rate of albuminuria is higher in older adults, the odds ratio of albuminuria in type 2 diabetes vs matched controls decreased with increasing age at diagnosis. For participants with diabetes diagnosed at an age of <50, 50 to 59, 60 to 69, or ≥70 years, the multivariable adjusted risk of albuminuria increased by 81%, 60%, 45%, and 33% for screen-detected diabetes, and 135%, 121%, 90%, and 58% for self-reported diabetes compared with their normal controls, respectively. CONCLUSIONS: A younger age at diagnosis of type 2 diabetes is associated with a more significantly elevated risk of albuminuria than an older age at diagnosis in Chinese adults.