Pauline Van Bulck1, Leen Cools1, Mysore S Soumya2, Dieudonné T Nyembue3, Patricia Kabobo3, Luo Zhang4, Glenis K Scadding5, Elina Toskala6, Wytske J Fokkens7, Brecht Steelant8, Peter W Hellings1,7,9. 1. Clinical Department of Otorhinolaryngology, Head and Neck Surgery, University Hospitals Leuven, Leuven, Belgium. 2. Department of ENT, St John's Medical College Hospital, Bangalore, India. 3. Department of Otolaryngology, University Hospitals Kinshasa, Kinshasa, Congo. 4. Department of Otolaryngology, Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China. 5. ENT Department Royal National Ear Nose and Throat Hospital, London, UK. 6. Department of Otolaryngology, Head and Neck Surgery, Temple University School of Medicine, Philadelphia, USA. 7. Department of Otolaryngology, Academic Medical Center, Amsterdam, The Netherlands. 8. KU Leuven Department of Microbiology, Immunology and Transplantation, Allergy and Clinical Immunology Research unit, Leuven, Belgium. 9. Department of Otorhinolaryngology-Head and Neck Surgery, Upper Airways Research Laboratory, Ghent University, Ghent, Belgium.
Abstract
BACKGROUND: Recent data show uncontrolled disease in 35% of allergic rhinitis (AR) patients on medical treatment. The reasons for uncontrolled disease can arbitrarily be divided into disease-related, diagnosis-related, treatment-related, and patient-related factors. However, the relative importance of these factors in uncontrolled disease remains speculative. This explorative study aimed at determining the factors causing uncontrolled AR on four different continents worldwide, identifying the most common reasons for uncontrolled disease in AR. METHODS: Patients with uncontrolled AR (n = 430) were asked to fill out a questionnaire and underwent a clinical examination at the outpatient clinic in five university outpatient clinics (Leuven [Belgium], Beijing [China], Kinshasa [Congo], Bangalore [India], and Philadelphia [US]). Two independent physicians evaluated the reason or multiple reasons for uncontrolled disease. The study was coordinated from the University Hospital of Leuven. RESULTS: In uncontrolled AR patients, 76% of patients showed two or more reasons for uncontrolled disease according to the physicians' evaluation. Disease-related factors (64%) were considered most often the reason for uncontrolled disease, followed by treatment- (56%), patient- (54%), and diagnosis-related (47%) factors. There is limited variability in observations across different centers worldwide. CONCLUSION: We here define the multiple reasons for uncontrolled AR across different continents, with disease-related factors being most frequently associated with uncontrolled disease. A better understanding of uncontrolled disease will guide us in defining strategies to improve AR care.
BACKGROUND: Recent data show uncontrolled disease in 35% of allergic rhinitis (AR) patients on medical treatment. The reasons for uncontrolled disease can arbitrarily be divided into disease-related, diagnosis-related, treatment-related, and patient-related factors. However, the relative importance of these factors in uncontrolled disease remains speculative. This explorative study aimed at determining the factors causing uncontrolled AR on four different continents worldwide, identifying the most common reasons for uncontrolled disease in AR. METHODS: Patients with uncontrolled AR (n = 430) were asked to fill out a questionnaire and underwent a clinical examination at the outpatient clinic in five university outpatient clinics (Leuven [Belgium], Beijing [China], Kinshasa [Congo], Bangalore [India], and Philadelphia [US]). Two independent physicians evaluated the reason or multiple reasons for uncontrolled disease. The study was coordinated from the University Hospital of Leuven. RESULTS: In uncontrolled AR patients, 76% of patients showed two or more reasons for uncontrolled disease according to the physicians' evaluation. Disease-related factors (64%) were considered most often the reason for uncontrolled disease, followed by treatment- (56%), patient- (54%), and diagnosis-related (47%) factors. There is limited variability in observations across different centers worldwide. CONCLUSION: We here define the multiple reasons for uncontrolled AR across different continents, with disease-related factors being most frequently associated with uncontrolled disease. A better understanding of uncontrolled disease will guide us in defining strategies to improve AR care.
Authors: Louise De Prins; Ulrike Raap; Tara Mueller; Peter Schmid-Grendelmeier; Christiane H Haase; Vibeke Backer; Wytske Fokkens; Linda B Benoist; Emmanuel Prokopakis; Claire Hopkins; Nele Claeys; Thijs Teeling; Lindsay Cypers; Leen Cools; Leif H Bjermer; Zuzana Diamant; Ulrich Wahn; Glenis Scadding; Claus Bachert; Sunni R Patel; Elizabeth Van Staeyen; Peter Hellings Journal: Front Allergy Date: 2022-06-02
Authors: Elisabeth Verhoeven; Philip Rouadi; Eliane Abou Jaoude; Mohamed Abouzakouk; Ignacio Ansotegui; Mona Al-Ahmad; Maryam Ali Al-Nesf; Cecilio Azar; Sami Bahna; Lyda Cuervo-Pardo; Zuzana Diamant; Habib Douagui; R Maximiliano Gómez; Sandra González Díaz; Joseph K Han; Samar Idriss; Carla Irani; Marilyn Karam; Ludger Klimek; Talal Nsouli; Glenis Scadding; Brent Senior; Pete Smith; Anahí Yáñez; Fares Zaitoun; Peter W Hellings Journal: World Allergy Organ J Date: 2022-06-23 Impact factor: 5.516