Mahsa Hatami 1 , Neda Soveid 2 , Azadeh Lesani 2 , Kurosh Djafarian 1 , Sakineh Shab-Bidar 2 Show Affiliations »
Abstract
BACKGROUND AND OBJECTIVE: Many studies have evaluated the risk of migraine headache in obese persons, suggesting controversial conclusions. The aim of this systematic review and meta- analysis of the observational studies was to clarify the association between migraine and obesity. METHODS: Scopus and PubMed electronic databases were systematically searched up to February 2019 for observational studies providing data dealing with migraine disorder in obese subjects, as well as normal-weight controls. The random effects model was applied for assessing pool effect size, and inter-study heterogeneity was evaluated by conducting subgroup analyses. RESULTS: Among 1122 publications, 16 studies (10 cross-sectional, 5 cohort studies and 1 case-control study) were detected and were included in the meta-analysis. The pooled data analysis illustrated an elevated risk of migraine headache (Prevalence ratio estimate = 1.29, 95% CI, 1.15 - 1.44, p = 0.000) in obese individuals compared to normal-weight persons. Subgroup analyses revealed that geographical distribution was an important source of heterogeneity (p = 0.04). Significantly greater migraine prevalence was found in European and Asian patients, but no statistically significant relationship with obesity was observed in American patients. CONCLUSION: Based on a cumulative meta-analysis of available studies indicating an association between migraine and obesity, obesity can be appropriately considered as an overall risk factor for migraine headaches. Additional high-quality original studies considering frequency, severity, and duration of headaches are required to clarify confident evidence. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
BACKGROUND AND OBJECTIVE: Many studies have evaluated the risk of migraine headache in obese persons, suggesting controversial conclusions. The aim of this systematic review and meta- analysis of the observational studies was to clarify the association between migraine and obesity. METHODS: Scopus and PubMed electronic databases were systematically searched up to February 2019 for observational studies providing data dealing with migraine disorder in obese subjects, as well as normal-weight controls. The random effects model was applied for assessing pool effect size, and inter-study heterogeneity was evaluated by conducting subgroup analyses. RESULTS: Among 1122 publications, 16 studies (10 cross-sectional, 5 cohort studies and 1 case-control study) were detected and were included in the meta-analysis. The pooled data analysis illustrated an elevated risk of migraine headache (Prevalence ratio estimate = 1.29, 95% CI, 1.15 - 1.44, p = 0.000) in obese individuals compared to normal-weight persons. Subgroup analyses revealed that geographical distribution was an important source of heterogeneity (p = 0.04). Significantly greater migraine prevalence was found in European and Asian patients, but no statistically significant relationship with obesity was observed in American patients. CONCLUSION: Based on a cumulative meta-analysis of available studies indicating an association between migraine and obesity, obesity can be appropriately considered as an overall risk factor for migraine headaches. Additional high-quality original studies considering frequency, severity, and duration of headaches are required to clarify confident evidence. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
Entities: Chemical
Keywords:
Obesity; body mass index; dyslipidemia; egger's test; migraine; observational studies.
Mesh： See more »
Year: 2021
PMID： 34259152 DOI： 10.2174/1871527320666210713114840
Source DB: PubMed Journal: CNS Neurol Disord Drug Targets ISSN： 1871-5273 Impact factor: 4.388