Agnieszka Pozdzik1,2, Cristina David1, Jelle Vekeman3, Frederik Tielens3, Michel Daudon4,5. 1. Department of Nephrology and Dialysis Kidney Stone Clinic Centre Hospitalier Universitaire Brugmann Hospital Brussels Belgium. 2. Faculty of Medicine Université Libre de Bruxelles (ULB) Brussels Belgium. 3. General Chemistry (ALGC) Materials Modelling Group Vrije Universiteit Brussels Brussels Belgium. 4. Service des explorations fonctionnelles multidisciplinaires Tenon Hospital AP_HP Paris France. 5. INSERM UMRS 1155 Université Pierre et Marie Curie-Paris VI-Sorbonne Universités Paris France.
Abstract
INTRODUCTION: The therapy to reduce urinary oxalate excretion in primary hyperoxaluria type 1 is still required. CASE PRESENTATION: A 37-year-old hemodialyzed man suffered from systemic oxalosis secondary to primary hyperoxaluria type 1 exhibited a drastic plasma oxalate decrease from 110 to 22 µmol/L two months after adjunction of lanthanum carbonate to classical treatment (intensive hemodialysis with pyridoxine). A 34-year-old woman with normal kidney function presented 10 years of bilateral kidney stones due to primary hyperoxaluria type 1 [hyperoxaluria (109.2 mg/24 h), plasma oxalate (56.0 µmol/L)]. The oxalate level remained uncontrolled despite of low oxalate-normal calcium diet, pyridoxine and increased water intake though the lanthanum carbonate adjunction resulted in significant decrease in plasma oxalate and oxaluria. CONCLUSION: We report the lanthanum efficacy in reducing circulating and urinary oxalate levels in type 1 primary hyperoxaluria. Possible mechanism of observed falls in oxalate concentration would be a decrease in the intestinal absorption of oxalate.
INTRODUCTION: The therapy to reduce urinary oxalate excretion in primary hyperoxaluria type 1 is still required. CASE PRESENTATION: A 37-year-old hemodialyzed man suffered from systemic oxalosis secondary to primary hyperoxaluria type 1 exhibited a drastic plasma oxalate decrease from 110 to 22 µmol/L two months after adjunction of lanthanum carbonate to classical treatment (intensive hemodialysis with pyridoxine). A 34-year-old woman with normal kidney function presented 10 years of bilateral kidney stones due to primary hyperoxaluria type 1 [hyperoxaluria (109.2 mg/24 h), plasma oxalate (56.0 µmol/L)]. The oxalate level remained uncontrolled despite of low oxalate-normal calcium diet, pyridoxine and increased water intake though the lanthanum carbonate adjunction resulted in significant decrease in plasma oxalate and oxaluria. CONCLUSION: We report the lanthanum efficacy in reducing circulating and urinary oxalate levels in type 1 primary hyperoxaluria. Possible mechanism of observed falls in oxalate concentration would be a decrease in the intestinal absorption of oxalate.
Authors: Geert J Behets; Geert Dams; Stephen J Damment; Patrick Martin; Marc E De Broe; Patrick C D'Haese Journal: Am J Physiol Renal Physiol Date: 2013-11-06
Authors: Sonia Fargue; Dawn S Milliner; John Knight; Julie B Olson; W Todd Lowther; Ross P Holmes Journal: J Am Soc Nephrol Date: 2018-03-27 Impact factor: 10.121