Erdem Sendinc1,2, David Valle-Garcia1,2,3, Alan Jiao1,2, Yang Shi4,5. 1. Division of Newborn Medicine and Epigenetics Program, Department of Medicine, Boston Children's Hospital, Boston, MA, 02115, USA. 2. Department of Cell Biology, Harvard Medical School, Boston, MA, 02115, USA. 3. Departamento de Medicina Molecular y Bioprocesos, Instituto de Biotecnologia, Universidad Nacional Autonoma de Mexico, Cuernavaca, Morelos, 62210, Mexico. 4. Division of Newborn Medicine and Epigenetics Program, Department of Medicine, Boston Children's Hospital, Boston, MA, 02115, USA. yang_shi@hms.harvard.edu. 5. Department of Cell Biology, Harvard Medical School, Boston, MA, 02115, USA. yang_shi@hms.harvard.edu.