Literature DB >> 34257008

Breakthroughs and bottlenecks in autophagy research.

Noboru Mizushima1, Eileen White2, David C Rubinsztein3.   

Abstract

The study of autophagy has grown exponentially over the past two decades, and significant progress has been made in our understanding of its mechanisms and physiological significance. However, its application to human diseases remains limited. Here, we summarize the current status of autophagy research, with a particular focus on human diseases.
Copyright © 2021 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  ATG genes; autophagic flux; macroautophagy; neurodegenerative disease; tumor growth

Mesh:

Year:  2021        PMID: 34257008     DOI: 10.1016/j.molmed.2021.06.012

Source DB:  PubMed          Journal:  Trends Mol Med        ISSN: 1471-4914            Impact factor:   11.951


  6 in total

Review 1.  Autophagy in health and disease: From molecular mechanisms to therapeutic target.

Authors:  Guang Lu; Yu Wang; Yin Shi; Zhe Zhang; Canhua Huang; Weifeng He; Chuang Wang; Han-Ming Shen
Journal:  MedComm (2020)       Date:  2022-07-10

Review 2.  Degradation Mechanism of Autophagy-Related Proteins and Research Progress.

Authors:  Yanhui Zhou; Hakim Manghwar; Weiming Hu; Fen Liu
Journal:  Int J Mol Sci       Date:  2022-06-30       Impact factor: 6.208

3.  Neuregulin-4 attenuates diabetic cardiomyopathy by regulating autophagy via the AMPK/mTOR signalling pathway.

Authors:  Hongchao Wang; Lijie Wang; Fuli Hu; Pengfei Wang; Yanan Xie; Fang Li; Bingyan Guo
Journal:  Cardiovasc Diabetol       Date:  2022-10-11       Impact factor: 8.949

4.  Vici syndrome in Israel: Clinical and molecular insights.

Authors:  Odelia Chorin; Yoel Hirsch; Rachel Rock; Liat Salzer Sheelo; Yael Goldberg; Hanna Mandel; Tova Hershkovitz; Nicole Fleischer; Lior Greenbaum; Uriel Katz; Ortal Barel; Nasrin Hamed; Bruria Ben-Zeev; Shoshana Greenberger; Nadra Nasser Samra; Michal Stern Zimmer; Annick Raas-Rothschild; Ben Pode-Shakked
Journal:  Front Genet       Date:  2022-09-20       Impact factor: 4.772

5.  A bibliometric analysis of autophagy in atherosclerosis from 2012 to 2021.

Authors:  Fengwei Zhang; Ruirui Wang; Baocheng Liu; Lei Zhang
Journal:  Front Pharmacol       Date:  2022-09-15       Impact factor: 5.988

Review 6.  The mTOR-lysosome axis at the centre of ageing.

Authors:  Julian M Carosi; Célia Fourrier; Julien Bensalem; Timothy J Sargeant
Journal:  FEBS Open Bio       Date:  2021-12-18       Impact factor: 2.693

  6 in total

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