| Literature DB >> 34256903 |
Greg M Delgoffe, Chenqi Xu, Crystal L Mackall, Michael R Green, Stephen Gottschalk, Daniel E Speiser, Dietmar Zehn, Paul A Beavis.
Abstract
CAR T cell therapy successes are challenged by several mechanisms of resistance including the development of dysfunctional states such as exhaustion. The features of CAR T cell exhaustion, its role in limiting the efficacy of CAR T therapy in both liquid and solid malignancies, and potential strategies to overcome it are discussed. CrownEntities:
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Year: 2021 PMID： 34256903 DOI： 10.1016/j.ccell.2021.06.012
Source DB: PubMed Journal: Cancer Cell ISSN： 1535-6108 Impact factor: 31.743