| Literature DB >> 34255846 |
Niall J Lennon1, Roby P Bhattacharyya1,2, Michael J Mina1,3,4, Heidi L Rehm1,2,3,5, Deborah T Hung1,2,3,5, Sandra Smole6, Ann Woolley1,3, Eric S Lander1,5,7, Stacey B Gabriel1.
Abstract
Transmission of coronavirus disease 2019 (COVID-19) from people without symptoms confounds societal mitigation strategies. From April to June 2020, we tested nasopharyngeal swabs by reverse transcriptase quantitative polymerase chain reaction (RT-qPCR) from 15 514 staff and 16 966 residents of nursing homes and assisted living facilities in Massachusetts. Cycle threshold (Ct) distributions were very similar between populations with (n = 739) and without (n = 2179) symptoms at the time of sampling (mean Ct, 25.7 vs 26.4; ranges 12-38). However, as local cases waned, those without symptoms shifted towards higher Ct. With such similar viral load distributions, existing testing modalities should perform comparably regardless of symptoms, contingent upon time since infection.Entities:
Keywords: COVID-19; SARS-CoV-2; molecular diagnostics; symptoms; viral load
Mesh：
Year: 2021 PMID： 34255846 PMCID： PMC8420626 DOI： 10.1093/infdis/jiab367
Source DB: PubMed Journal: J Infect Dis ISSN： 0022-1899 Impact factor: 7.759