Shireen Sindi1,2, Ingemar Kåreholt3,4, Tiia Ngandu5, Anna Rosenberg6, Jenni Kulmala1,5, Lena Johansson7, Hanna Wetterberg7, Johan Skoog8, Linnea Sjöberg3, Hui-Xin Wang3,9, Laura Fratiglioni3,10, Ingmar Skoog7, Miia Kivipelto1,2,6,11. 1. Division of Clinical Geriatrics, Center for Alzheimer Research, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden. 2. Ageing Epidemiology (AGE) Research Unit, School of Public Health, Imperial College London, London, UK. 3. Aging Research Center, Karolinska Institutet and Stockholm University, Stockholm, Sweden. 4. Institute of Gerontology, School of Health and Welfare, Aging Research Network - Jönköping (ARN-J), Jönköping University, Jönköping, Sweden. 5. Public Health Promotion Unit, National Institute for Health and Welfare, Helsinki, Finland. 6. Institute of Public Health and Clinical Nutrition and Institute of Clinical Medicine, Neurology, University of Eastern Finland, Kuopio, Finland. 7. Institute of Neuroscience and Physiology, Center for Health and Ageing AGECAP, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. 8. Department of Psychology, Center for Health and Ageing (AGECAP), University of Gothenburg, Gothenburg, Sweden. 9. Stress Research Institute, Stockholom University, Stockholm, Sweden. 10. Stockholm Gerontology Research Center, Stockholm, Sweden. 11. Theme Aging, Karolinska University Hospital, Stockholm, Sweden.
Abstract
INTRODUCTION: Evidence on sex differences in the risk for dementia has been mixed. The goal was to assess sex differences in the development of dementia, and in the effects of a lifestyle intervention. METHODS: Two strategies were adopted, one using combined data from three large Nordic population-based cohort studies (n = 2289), adopting dementia as outcome, and 2-year multidomain lifestyle intervention (n = 1260), adopting cognitive change as outcome. RESULTS: There was higher risk for dementia after age 80 years in women. The positive effects of the lifestyle intervention on cognition did not significantly differ between men and women. Sex-specific analyses suggested that different vascular, lifestyle, and psychosocial risk factors are important for women and men in mid- and late-life. CONCLUSION: Women had higher risk for dementia among the oldest individuals. Lifestyle interventions may be effectively implemented among older men and women.
INTRODUCTION: Evidence on sex differences in the risk for dementia has been mixed. The goal was to assess sex differences in the development of dementia, and in the effects of a lifestyle intervention. METHODS: Two strategies were adopted, one using combined data from three large Nordic population-based cohort studies (n = 2289), adopting dementia as outcome, and 2-year multidomain lifestyle intervention (n = 1260), adopting cognitive change as outcome. RESULTS: There was higher risk for dementia after age 80 years in women. The positive effects of the lifestyle intervention on cognition did not significantly differ between men and women. Sex-specific analyses suggested that different vascular, lifestyle, and psychosocial risk factors are important for women and men in mid- and late-life. CONCLUSION:Women had higher risk for dementia among the oldest individuals. Lifestyle interventions may be effectively implemented among older men and women.
Authors: Patrick J Smith; Andrew Sherwood; Alan L Hinderliter; Stephanie Mabe; Lana L Watkins; Linda Craighead; Krista Ingle; Crystal Tyson; Forgive Avorgbedor; Pao-Hwa Lin; William E Kraus; Lawrence Liao; James A Blumenthal Journal: J Hypertens Date: 2022-06-10 Impact factor: 4.776
Authors: Klodian Dhana; Oscar H Franco; Ethan M Ritz; Christopher N Ford; Pankaja Desai; Kristin R Krueger; Thomas M Holland; Anisa Dhana; Xiaoran Liu; Neelum T Aggarwal; Denis A Evans; Kumar B Rajan Journal: BMJ Date: 2022-04-13