Literature DB >> 34252296

Genetic Context of optrA and poxtA in Florfenicol-Resistant Enterococci Isolated from Flowing Surface Water in Switzerland.

Michael Biggel1, Magdalena Nüesch-Inderbinen1, Christoph Jans2, Marc J A Stevens1, Roger Stephan1.   

Abstract

Linezolid is an important last-resort antibiotic for the treatment of multidrug-resistant enterococci. The aim of this study was to further characterize the genetic context of optrA and poxtA in 10 florfenicol-resistant enterococci isolated from flowing surface water. In most genomes, optrA and poxtA were embedded in transposition units integrated into plasmids or into the chromosomal radC. For the first time, a chromosomally integrated optrA in an Enterococcus raffinosus isolate is described.

Entities:  

Keywords:  Enterococcus; linezolid resistance; optrA; poxtA; surface water

Mesh：

Substances：

Year:  2021        PMID： 34252296      PMCID： PMC8448137          DOI： 10.1128/AAC.01083-21

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  21 in total

1.  Detection of the phenicol-oxazolidinone-tetracycline resistance gene poxtA in Enterococcus faecium and Enterococcus faecalis of food-producing animal origin in China.

Authors:  Chang-Wei Lei; Zhuang-Zhuang Kang; Shun-Kang Wu; Yan-Peng Chen; Ling-Han Kong; Hong-Ning Wang
Journal:  J Antimicrob Chemother       Date:  2019-08-01       Impact factor: 5.790

2.  Prokka: rapid prokaryotic genome annotation.

Authors:  Torsten Seemann
Journal:  Bioinformatics       Date:  2014-03-18       Impact factor: 6.937

3.  Genetic features of the poxtA linezolid resistance gene in human enterococci from France.

Authors:  Loren Dejoies; Mohamed Sassi; Sacha Schutz; Julie Moreaux; Asma Zouari; Sophie Potrel; Anaïs Collet; Maxime Lecourt; Gabriel Auger; Vincent Cattoir
Journal:  J Antimicrob Chemother       Date:  2021-04-25       Impact factor: 5.790

4.  Characterization of poxtA, a novel phenicol-oxazolidinone-tetracycline resistance gene from an MRSA of clinical origin.

Authors:  Alberto Antonelli; Marco Maria D'Andrea; Andrea Brenciani; Cesira L Galeotti; Gianluca Morroni; Simona Pollini; Pietro Emanuele Varaldo; Gian Maria Rossolini
Journal:  J Antimicrob Chemother       Date:  2018-07-01       Impact factor: 5.790

5.  The oxazolidinone antibiotics perturb the ribosomal peptidyl-transferase center and effect tRNA positioning.

Authors:  Daniel N Wilson; Frank Schluenzen; Joerg M Harms; Agata L Starosta; Sean R Connell; Paola Fucini
Journal:  Proc Natl Acad Sci U S A       Date:  2008-08-29       Impact factor: 11.205

6.  Identification of acquired antimicrobial resistance genes.

Authors:  Ea Zankari; Henrik Hasman; Salvatore Cosentino; Martin Vestergaard; Simon Rasmussen; Ole Lund; Frank M Aarestrup; Mette Voldby Larsen
Journal:  J Antimicrob Chemother       Date:  2012-07-10       Impact factor: 5.790

7.  Dissemination of Linezolid Resistance Through Sex Pheromone Plasmid Transfer in Enterococcus faecalis.

Authors:  Jiaqi Zou; Zhaobing Tang; Jia Yan; Hang Liu; Yingzhu Chen; Dawei Zhang; Jinxin Zhao; Yu Tang; Jing Zhang; Yun Xia
Journal:  Front Microbiol       Date:  2020-06-04       Impact factor: 5.640

8.  RefSeq: an update on prokaryotic genome annotation and curation.

Authors:  Daniel H Haft; Michael DiCuccio; Azat Badretdin; Vyacheslav Brover; Vyacheslav Chetvernin; Kathleen O'Neill; Wenjun Li; Farideh Chitsaz; Myra K Derbyshire; Noreen R Gonzales; Marc Gwadz; Fu Lu; Gabriele H Marchler; James S Song; Narmada Thanki; Roxanne A Yamashita; Chanjuan Zheng; Françoise Thibaud-Nissen; Lewis Y Geer; Aron Marchler-Bauer; Kim D Pruitt
Journal:  Nucleic Acids Res       Date:  2018-01-04       Impact factor: 16.971

9.  Comparative genomics of global optrA-carrying Enterococcus faecalis uncovers a common chromosomal hotspot for optrA acquisition within a diversity of core and accessory genomes.

Authors:  Ana R Freitas; Ana P Tedim; Carla Novais; Val F Lanza; Luísa Peixe
Journal:  Microb Genom       Date:  2020-03-09

10.  Characterization of a Multiresistance Plasmid Carrying the optrA and cfr Resistance Genes From an Enterococcus faecium Clinical Isolate.

Authors:  Gianluca Morroni; Andrea Brenciani; Alberto Antonelli; Marco Maria D'Andrea; Vincenzo Di Pilato; Simona Fioriti; Marina Mingoia; Carla Vignaroli; Oscar Cirioni; Francesca Biavasco; Pietro E Varaldo; Gian Maria Rossolini; Eleonora Giovanetti
Journal:  Front Microbiol       Date:  2018-09-11       Impact factor: 5.640
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  1 in total

1.  Faecal carriage of enterococci harbouring oxazolidinone resistance genes among healthy humans in the community in Switzerland.

Authors:  Magdalena Nüesch-Inderbinen; Michael Biggel; Katrin Zurfluh; Andrea Treier; Roger Stephan
Journal:  J Antimicrob Chemother       Date:  2022-09-30       Impact factor: 5.758
  1 in total

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