Amal F Alshammary1, Abdulrahman M Al-Sulaiman2. 1. Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia. 2. Department of Medical and Molecular Virology, Prince Sultan Military Medical City, Riyadh, Saudi Arabia.
Abstract
Coronavirus disease 2019 (COVID-19) is a highly infectious viral disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Laboratory findings from a significant number of patients with COVID-19 indicate the occurrence of leukocytopenia, specifically lymphocytopenia. Moreover, infected patients can experience contrasting outcomes depending on lymphocytopenia status. Patients with resolved lymphocytopenia are more likely to recover, whereas critically ill patients with signs of unresolved lymphocytopenia develop severe complications, sometimes culminating in death. Why immunodepression manifests in patients with COVID-19 remains unclear. Therefore, the evaluation of clinical symptoms and laboratory findings from infected patients is critical for understanding the disease course and its consequences. In this review, we take a logical approach to unravel the reasons for immunodepression in patients with COVID-19. Following the footprints of the virus within host tissues, from entry to exit, we extrapolate the mechanisms underlying the phenomenon of immunodepression.
Coronavirus disease 2019 (n class="Disease">COVID-19) is a highly infectiousviral disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Laboratory findings from a significant number of patients with COVID-19 indicate the occurrence of leukocytopenia, specifically lymphocytopenia. Moreover, infectedpatients can experience contrasting outcomes depending on lymphocytopenia status. Patients with resolved lymphocytopenia are more likely to recover, whereas critically illpatients with signs of unresolved lymphocytopenia develop severe complications, sometimes culminating in death. Why immunodepression manifests in patients with COVID-19 remains unclear. Therefore, the evaluation of clinical symptoms and laboratory findings from infectedpatients is critical for understanding the disease course and its consequences. In this review, we take a logical approach to unravel the reasons for immunodepression in patients with COVID-19. Following the footprints of the virus within host tissues, from entry to exit, we extrapolate the mechanisms underlying the phenomenon of immunodepression.
Authors: Amal F Alshammary; Jawaher M Alsughayyir; Khalid K Alharbi; Abdulrahman M Al-Sulaiman; Haifa F Alshammary; Heba F Alshammary Journal: Front Med (Lausanne) Date: 2022-04-28
Authors: Alejandro Peralta-Garcia; Mariona Torrens-Fontanals; Tomasz Maciej Stepniewski; Judith Grau-Expósito; David Perea; Vikram Ayinampudi; Maria Waldhoer; Mirjam Zimmermann; María J Buzón; Meritxell Genescà; Jana Selent Journal: Int J Mol Sci Date: 2021-12-18 Impact factor: 5.923