| Literature DB >> 34251595 |
Satoshi Nojima1, Masaharu Kohara1, Hiroshi Harada2, Hitomi Kajikawa3, Katsutoshi Hirose4, Shin-Ichi Nakatsuka2, Yukinobu Nakagawa5, Kaori Oya6, Yasuo Fukuda6, Kazuhide Matsunaga3, Narikazu Uzawa3, Manabu Fujimoto5, Satoru Toyosawa4, Eiichi Morii7.
Abstract
Clear cell carcinoma (CCC) is a rare epithelial malignant tumor of the salivary glands. It is characterized by tumor cells with clear cytoplasm, hyalinized stroma, and most importantly the fusion genes EWSR1-ATF1, EWSR1-CREM, and EWSR1-PLAG1. Break-apart FISH has been performed for multiple CCC cases, but direct sequencing analysis has been performed in relatively few. Herein, we report an interesting case of CCC harboring three EWSR1-ATF1 translocations: EWSR1 exon 8-ATF1 exon 4, EWSR1 exon 7-ATF1 exon 4, and EWSR1 exon 7-ATF1 exon 5. This case indicates the possibility of independent EWSR1-ATF1 gene translocations, and could provide insight into CCC tumorgenesis.Entities:
Keywords: ATF1; Clear cell carcinoma; EWSR1; Hyalinizing clear cell carcinoma; Salivary duct tumor
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Year: 2021 PMID： 34251595 PMCID： PMC9187791 DOI： 10.1007/s12105-021-01356-y
Source DB: PubMed Journal: Head Neck Pathol ISSN： 1936-055X