Literature DB >> 34251046

Health equality, race and pharmacogenomics.

Emma F Magavern1, Deepti Gurdasani1, Fu L Ng2, Sandra Soo-Jin Lee3.   

Abstract

Pharmacogenomics is increasingly moving into mainstream clinical practice. Careful consideration must be paid to inclusion of diverse populations in research, translation and implementation, in the historical and social context of population stratification, to ensure that this leads to improvements in healthcare for all rather than increased health disparities. This review takes a broad and critical approach to the current role of diversity in pharmacogenomics and addresses potential pitfalls in order to raise awareness for prescribers. It also emphasizes evidence gaps and suggests approaches that may minimize negative consequences and promote health equality.
© 2021 British Pharmacological Society.

Entities:  

Keywords:  bioethics; pharmacogenomics; pharmacotherapy; therapeutics

Mesh:

Year:  2021        PMID: 34251046      PMCID: PMC8752640          DOI: 10.1111/bcp.14983

Source DB:  PubMed          Journal:  Br J Clin Pharmacol        ISSN: 0306-5251            Impact factor:   4.335


  41 in total

1.  When two tribes go to war.

Authors:  Rex Dalton
Journal:  Nature       Date:  2004-07-29       Impact factor: 49.962

2.  Standardized Biogeographic Grouping System for Annotating Populations in Pharmacogenetic Research.

Authors:  Rachel Huddart; Alison E Fohner; Michelle Whirl-Carrillo; Genevieve L Wojcik; Christopher R Gignoux; Alice B Popejoy; Carlos D Bustamante; Russ B Altman; Teri E Klein
Journal:  Clin Pharmacol Ther       Date:  2019-01-21       Impact factor: 6.875

3.  Illuminating BiDil.

Authors: 
Journal:  Nat Biotechnol       Date:  2005-08       Impact factor: 54.908

4.  BiDil: assessing a race-based pharmaceutical.

Authors:  Howard Brody; Linda M Hunt
Journal:  Ann Fam Med       Date:  2006 Nov-Dec       Impact factor: 5.166

5.  Sequence variations in PCSK9, low LDL, and protection against coronary heart disease.

Authors:  Jonathan C Cohen; Eric Boerwinkle; Thomas H Mosley; Helen H Hobbs
Journal:  N Engl J Med       Date:  2006-03-23       Impact factor: 91.245

6.  HLA-B*5701 screening for hypersensitivity to abacavir.

Authors:  Simon Mallal; Elizabeth Phillips; Giampiero Carosi; Jean-Michel Molina; Cassy Workman; Janez Tomazic; Eva Jägel-Guedes; Sorin Rugina; Oleg Kozyrev; Juan Flores Cid; Phillip Hay; David Nolan; Sara Hughes; Arlene Hughes; Susanna Ryan; Nicholas Fitch; Daren Thorborn; Alastair Benbow
Journal:  N Engl J Med       Date:  2008-02-07       Impact factor: 91.245

Review 7.  Genomics of disease risk in globally diverse populations.

Authors:  Deepti Gurdasani; Inês Barroso; Eleftheria Zeggini; Manjinder S Sandhu
Journal:  Nat Rev Genet       Date:  2019-06-24       Impact factor: 53.242

8.  The African Genome Variation Project shapes medical genetics in Africa.

Authors:  Deepti Gurdasani; Tommy Carstensen; Fasil Tekola-Ayele; Luca Pagani; Ioanna Tachmazidou; Konstantinos Hatzikotoulas; Savita Karthikeyan; Louise Iles; Martin O Pollard; Ananyo Choudhury; Graham R S Ritchie; Yali Xue; Jennifer Asimit; Rebecca N Nsubuga; Elizabeth H Young; Cristina Pomilla; Katja Kivinen; Kirk Rockett; Anatoli Kamali; Ayo P Doumatey; Gershim Asiki; Janet Seeley; Fatoumatta Sisay-Joof; Muminatou Jallow; Stephen Tollman; Ephrem Mekonnen; Rosemary Ekong; Tamiru Oljira; Neil Bradman; Kalifa Bojang; Michele Ramsay; Adebowale Adeyemo; Endashaw Bekele; Ayesha Motala; Shane A Norris; Fraser Pirie; Pontiano Kaleebu; Dominic Kwiatkowski; Chris Tyler-Smith; Charles Rotimi; Eleftheria Zeggini; Manjinder S Sandhu
Journal:  Nature       Date:  2014-12-03       Impact factor: 49.962

9.  A standardized framework for representation of ancestry data in genomics studies, with application to the NHGRI-EBI GWAS Catalog.

Authors:  Joannella Morales; Danielle Welter; Emily H Bowler; Maria Cerezo; Laura W Harris; Aoife C McMahon; Peggy Hall; Heather A Junkins; Annalisa Milano; Emma Hastings; Cinzia Malangone; Annalisa Buniello; Tony Burdett; Paul Flicek; Helen Parkinson; Fiona Cunningham; Lucia A Hindorff; Jacqueline A L MacArthur
Journal:  Genome Biol       Date:  2018-02-15       Impact factor: 13.583

View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.