[Thrombophilia caused by a type II protein-C defect].

It is reported on the first cases of protein C deficiency of type II detected in the GDR. This type of the defect is characterized by a normal antigen content in definitely decreased activity of protein C. Among 29 patients who became evident due to spontaneous and/or relapsing thromboses, the defect was found in 6 cases. In family investigations further asymptomatic carriers of characteristics were found in two families not related to each other. The clinical consequences are discussed.