Blaise Simplice Talla Nwotchouang1, Alaaddin Ibrahimy2, Dorothy M Loth3, Edward Labuda3, Nicholas Labuda3, Maggie Eppleheimer3, Richard Labuda4, Jayapalli Rajiv Bapuraj5, Philip A Allen6, Petra Klinge7, Francis Loth2. 1. Conquer Chiari Research Center, Department of Mechanical Engineering, The University of Akron, Akron, OH, USA. bn23@uakron.edu. 2. Conquer Chiari Research Center, Department of Mechanical Engineering, The University of Akron, Akron, OH, USA. 3. Conquer Chiari Research Center, The University of Akron, Akron, OH, USA. 4. Conquer Chiari, Wexford, PA, USA. 5. Department of Radiology, University of Michigan Health System, Ann Arbor, MI, USA. 6. Conquer Chiari Research Center, Department of Psychology, The University of Akron, Akron, OH, USA. 7. The Warren Alpert Medical School of Brown University, Providence, RI, USA.
Abstract
PURPOSE: Incidental cerebellar tonsillar ectopia (ICTE) that meets the radiographic criterion for Chiari malformation type I (CMI) is an increasingly common finding in the clinical setting, but its significance is unclear. The present study examined posterior cranial fossa (PCF) morphometrics and a broad range of health instruments of pediatric ICTE cases and matched controls extracted from the Adolescent Brain Cognitive Development (ABCD) dataset. METHODS: One-hundred-six subjects with ICTE and 106 matched controls without ICTE were identified from 11,411 anatomical MRI of healthy screened pediatric subjects from the ABCD project. Subjects were matched by sex, age, body mass index, race, and ethnicity. Twenty-two brain morphometrics and 22 health instruments were compared between the two groups to identify unrecognized CMI symptoms and assess the general health impact of ICTE. RESULTS: Twelve and 15 measures were significantly different between the ICTE and control groups for females and males, respectively. Notably, for females, the anterior CSF space was significantly smaller (p = 0.00005) for the ICTE group than controls. For males, the clivus bone length was significantly shorter (p = 0.0002) for the ICTE group compared to controls. No significant differences were found among the 22 health instruments between the two groups. CONCLUSION: This study demonstrated that pediatric ICTE subjects have similar PCF morphometrics to adult CMI. ICTE alone did not appear to cause any unrecognized CMI symptoms and had no impact on the subjects' current mental, physical, or behavioral health. Still, given their cranial and brain morphology, these cases may be at risk for adult-onset symptomatic CMI.
PURPOSE: Incidental cerebellar tonsillar ectopia (ICTE) that meets the radiographic criterion for Chiari malformation type I (CMI) is an increasingly common finding in the clinical setting, but its significance is unclear. The present study examined posterior cranial fossa (PCF) morphometrics and a broad range of health instruments of pediatric ICTE cases and matched controls extracted from the Adolescent Brain Cognitive Development (ABCD) dataset. METHODS: One-hundred-six subjects with ICTE and 106 matched controls without ICTE were identified from 11,411 anatomical MRI of healthy screened pediatric subjects from the ABCD project. Subjects were matched by sex, age, body mass index, race, and ethnicity. Twenty-two brain morphometrics and 22 health instruments were compared between the two groups to identify unrecognized CMI symptoms and assess the general health impact of ICTE. RESULTS: Twelve and 15 measures were significantly different between the ICTE and control groups for females and males, respectively. Notably, for females, the anterior CSF space was significantly smaller (p = 0.00005) for the ICTE group than controls. For males, the clivus bone length was significantly shorter (p = 0.0002) for the ICTE group compared to controls. No significant differences were found among the 22 health instruments between the two groups. CONCLUSION: This study demonstrated that pediatric ICTE subjects have similar PCF morphometrics to adult CMI. ICTE alone did not appear to cause any unrecognized CMI symptoms and had no impact on the subjects' current mental, physical, or behavioral health. Still, given their cranial and brain morphology, these cases may be at risk for adult-onset symptomatic CMI.
Authors: R Shane Tubbs; Joshua Beckman; Robert P Naftel; Joshua J Chern; John C Wellons; Curtis J Rozzelle; Jeffrey P Blount; W Jerry Oakes Journal: J Neurosurg Pediatr Date: 2011-03 Impact factor: 2.375
Authors: Laurence Davidson; Tiffany N Phan; John S Myseros; Suresh N Magge; Chima Oluigbo; Carlos E Sanchez; Robert F Keating Journal: Childs Nerv Syst Date: 2020-11-23 Impact factor: 1.475