Literature DB >> 3424411

The stability of 5,6-dihydrofluorouracil in plasma and the consequences for its analysis.

N van den Bosch1, O Driessen, E A van der Velde, C Erkelens.   

Abstract

This study shows that 5,6-dihydrofluorouracil kept in plasma at room temperature deteriorates in time. Preservation is gained by low temperature and low pH of plasma samples. Therefore, plasma samples should be buffered and frozen immediately after being obtained, and thawing should proceed to 5 degrees C only.

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Year:  1987        PMID： 3424411     DOI： 10.1097/00007691-198712000-00014

Source DB:  PubMed          Journal:  Ther Drug Monit        ISSN： 0163-4356            Impact factor:   3.681


  2 in total

1.  Pharmacokinetics and bioavailability of oral 5'-deoxy-5-fluorouridine in cancer patients.

Authors:  S A Van Der Heyden; M S Highley; E A De Bruijn; U R Tjaden; H J Reeuwijk; H Van Slooten; A T Van Oosterom; R A Maes
Journal:  Br J Clin Pharmacol       Date:  1999-04       Impact factor: 4.335

2.  Measurement of in vitro cellular pharmacokinetics of 5-fluorouracil in human and rat cancer cell lines and rat hepatocytes using a flow-through system.

Authors:  E C Spoelstra; H M Pinedo; H Dekker; G J Peters; J Lankelma
Journal:  Cancer Chemother Pharmacol       Date:  1991       Impact factor: 3.333
  2 in total

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