Giuseppe Muscogiuri1, Laura Fusini1, Francesca Ricci2, Rita Sicuso3, Marco Guglielmo1, Andrea Baggiano1, Alessio Gasperetti4, Michela Casella5, Saima Mushtaq1, Edoardo Conte1, Andrea Annoni1, Alberto Formenti1, Maria Elisabetta Mancini1, Mario Babbaro6, Rocco Mollace7, Ada Collevecchio8, Stefano Scafuri9, Deni Kukavica10, Daniele Andreini11, Cristina Basso8, Stefania Rizzo8, Monica De Gaspari8, Silvia Priori10, Antonio Dello Russo12, Claudio Tondo3, Mauro Pepi1, Elena Sommariva1, Mark Rabbat13, Andrea Igoren Guaricci14, Gianluca Pontone15. 1. Centro Cardiologico Monzino, IRCCS, Milan, Italy. 2. Istituto di radiologia, Fondazione policlinico universitario Agostino gemelli IRCSS Università Cattolica del Sacro Cuore, Rome, Italy. 3. Heart Rhythm Center, Centro Cardiologico Monzino IRCCS, Milan, Italy. 4. University Heart Center, University Hospital Zurich, Switzerland. 5. Cardiology and Arrhythmology Clinic, Department of Clinical, Special and Dental Sciences, University Hospital "Umberto I - Lancisi - Salesi", Marche Polytechnic University, Ancona, Italy. 6. Department of Clinical and Molecular Medicine, Faculty of Medicine and Psychology, Sapienza University of Rome, Italy. 7. Division of Cardiology, University Hospital Policlinico Tor Vergata, Rome, Italy. 8. Cardiovascular Pathology, Azienda Ospedaliera, Department of Cardiac, Thoracic and Vascular Sciences and Public Health, University of Padua, Padua, Italy. 9. Interventional Cardiology Unit, Mediterranea Cardiocentro, Naples, Italy. 10. Department of Molecular Medicine, University of Pavia, Pavia, Italy; IRCCS Istituti Clinici Scientifici Maugeri, Pavia, Italy. 11. Centro Cardiologico Monzino, IRCCS, Milan, Italy; Department of Cardiovascular Sciences and Community Health, University of Milan, Milan, Italy. 12. Cardiology and Arrhythmology Clinic, Department of Biomedical Sciences and Public Health, University Hospital "Umberto I - Lancisi - Salesi", Marche Polytechnic University, Ancona, Italy. 13. Loyola University of Chicago, Chicago, IL, United States of America; Edward Hines Jr. VA Hospital, Hines, IL, United States of America. 14. Institute of Cardiovascular Disease, Department of Emergency and Organ Transplantation, University Hospital "Policlinico Consorziale" of Bari, Bari, Italy. 15. Centro Cardiologico Monzino, IRCCS, Milan, Italy. Electronic address: gianluca.pontone@ccfm.it.
Abstract
BACKGROUND: We aim to evaluate the value of Cardiac magnetic resonance (CMR) feature tracking (CMR-FT) in addition to Task Force Criteria(TFC) in patients with (arrhythmogenic cardiomyopathy) AC biopsy-proved. METHODS: Thirty-five patients with AC histologically proven who performed CMR with late gadolinium enhancement (LGE) acquisition were enrolled. The study population was divided in Group1 (negative CMR TFC and LV ejection fraction≥55%) and Group2 (positive CMR TFC and/or LVEF<55%) and compared to an age and gender-matched control group. CMR datasets of all patients were analyzed to calculate LV indexed end-diastolic (LVEDi) and end-systolic (LVESi) volumes and RV indexed end-diastolic (RVEDi) and end-systolic (RVESi) volumes, both LV ejection fraction (LVEF) and RV ejection fraction (RVEF). Moreover, LV and RV global longitudinal (GLS), circumferential (GCS) and radial (GRS) strain were measured . RESULTS: The AC patients showed both higher LVEDi (p:0.002) and RVEDi (p:0.017) and lower LVEF (p: 0.016) as compared to control patients. Moreover, AC patients showed impaired LV-GLS (p < 0.001), LV-GRS (p < 0.001), LV-GCS (p < 0.001) and RV-GRS (p:0.026) as compared to control subjects. Group1 patients showed a significant reduction of LV-GRS (p < 0.05) and LV-GCS p < 0.01) as compared to control subjects. At univariate analysis LV-GCS was the most discriminatory parameter between Group1 vs heathy subjects with an optimal cut-off of -15.8 (Sensitivity: 74%; Specificity: 10%). CONCLUSIONS: In patients with AC biopsy-proven, CMR-FT could improve the diagnostic yield in the subset of patients who results negative for imaging TFC criteria resulting as useful gatekeeper for indication of myocardial biopsy in case of equivocal clinical and imaging presentation.
BACKGROUND: We aim to evaluate the value of Cardiac magnetic resonance (CMR) feature tracking (CMR-FT) in addition to Task Force Criteria(TFC) in patients with (arrhythmogenic cardiomyopathy) AC biopsy-proved. METHODS: Thirty-five patients with AC histologically proven who performed CMR with late gadolinium enhancement (LGE) acquisition were enrolled. The study population was divided in Group1 (negative CMR TFC and LV ejection fraction≥55%) and Group2 (positive CMR TFC and/or LVEF<55%) and compared to an age and gender-matched control group. CMR datasets of all patients were analyzed to calculate LV indexed end-diastolic (LVEDi) and end-systolic (LVESi) volumes and RV indexed end-diastolic (RVEDi) and end-systolic (RVESi) volumes, both LV ejection fraction (LVEF) and RV ejection fraction (RVEF). Moreover, LV and RV global longitudinal (GLS), circumferential (GCS) and radial (GRS) strain were measured . RESULTS: The AC patients showed both higher LVEDi (p:0.002) and RVEDi (p:0.017) and lower LVEF (p: 0.016) as compared to control patients. Moreover, AC patients showed impaired LV-GLS (p < 0.001), LV-GRS (p < 0.001), LV-GCS (p < 0.001) and RV-GRS (p:0.026) as compared to control subjects. Group1 patients showed a significant reduction of LV-GRS (p < 0.05) and LV-GCS p < 0.01) as compared to control subjects. At univariate analysis LV-GCS was the most discriminatory parameter between Group1 vs heathy subjects with an optimal cut-off of -15.8 (Sensitivity: 74%; Specificity: 10%). CONCLUSIONS: In patients with AC biopsy-proven, CMR-FT could improve the diagnostic yield in the subset of patients who results negative for imaging TFC criteria resulting as useful gatekeeper for indication of myocardial biopsy in case of equivocal clinical and imaging presentation.
Authors: Emanuele Di Virgilio; Francesco Monitillo; Daniela Santoro; Silvia D'Alessandro; Marco Guglielmo; Andrea Baggiano; Laura Fusini; Riccardo Memeo; Mark G Rabbat; Stefano Favale; Matteo Cameli; Andrea Igoren Guaricci; Gianluca Pontone Journal: J Clin Med Date: 2021-11-30 Impact factor: 4.241
Authors: Alberico Del Torto; Andrea Igoren Guaricci; Francesca Pomarico; Marco Guglielmo; Laura Fusini; Francesco Monitillo; Daniela Santoro; Monica Vannini; Alexia Rossi; Giuseppe Muscogiuri; Andrea Baggiano; Gianluca Pontone Journal: Front Cardiovasc Med Date: 2022-03-09
Authors: Karuna M Das; Usama M A Baskaki; Anisha Pulinchani; Huthaifa M Ali; Taleb M Almanssori; Klaus Van Gorkom; Amrita Das; Hany Dewedar; Sanjiv Sharma Journal: Diagnostics (Basel) Date: 2022-08-09