Kiyoto Shiga1, Ken-Ichi Nibu2, Yasushi Fujimoto3, Takahiro Asakage4, Akihiro Homma5, Hiroki Mitani6, Takenori Ogawa7, Kenji Okami8, Shigeyuki Murono9, Shigeru Hirano10, Tsutomu Ueda11, Nobuhiro Hanai12, Kiyoaki Tsukahara13, Ichiro Ota14, Seiichi Yoshimoto15, Takeshi Shinozaki16, Shigemichi Iwae17, Katsunori Katagiri1, Daisuke Saito1, Naomi Kiyota18, Makoto Tahara19, Fumiaki Takahashi20, Ryuichi Hayashi16. 1. Department of Head and Neck Surgery, Iwate Medical University School of Medicine, Yahaba, Japan. 2. Department of Otolaryngology - Head and Neck Surgery, Kobe University Graduate School of Medicine, Kobe, Japan. 3. Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Japan. 4. Department of Head and Neck Surgery, Tokyo Medical and Dental University, Tokyo, Japan. 5. Department of Otolaryngology - Head and Neck Surgery, Faculty of Medicine, Graduate School of Medicine, Hokkaido University, Sapporo, Japan. 6. Department of Head and Neck Surgery, Cancer Institute Hospital of JFCR, Tokyo, Japan. 7. Department of Otolaryngology - Head and Neck Surgery, Tohoku University Hospital, Sendai, Japan. 8. Department of Otolaryngology, Tokai University School of Medicine, Isehara, Japan. 9. Department of Otolaryngology, Fukushima Medical University, Fukushima, Japan. 10. Department of Otolaryngology - Head and Neck Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan. 11. Department of Otorhinolaryngology - Head and Neck Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan. 12. Department of Head and Neck Surgery, Aichi Cancer Center Hospital, Nagoya, Japan. 13. Department of Otorhinolaryngology - Head and Neck Surgery, Tokyo Medical University, Tokyo, Japan. 14. Department of Otolaryngology - Head and Neck Surgery, Nara Medical University, Kashihara, Japan. 15. Department of Head and Neck Surgery, National Cancer Center Hospital, Tokyo, Japan. 16. Department of Head and Neck Surgery, National Cancer Center Hospital East, Kashiwa, Japan. 17. Department of Head and Neck Surgery, Hyogo Cancer Center, Akashi, Japan. 18. Department of Medical Oncology/Hematology, Kobe University Hospital Cancer Center, Kobe, Japan. 19. Department of Head and Neck Medical Oncology, National Cancer Center Hospital East, Kashiwa, Japan. 20. Division of Medical Engineering, Department of Information Science, Iwate Medical University, Yahaba, Japan.
Abstract
BACKGROUND: This study aimed to reveal the influence of the invasion site of external auditory canal (EAC) cancer by analyzing the outcome of patients with advanced tumor. METHODS: A total of 111 patients with T4 EAC cancer were enrolled in this study. Of these patients, 79 underwent chemoradiotherapy and 32 underwent surgery under curative intent. Univariate and multivariate analyses and the Kaplan-Meier method were used to focus on the tumor invasion sites and overall survival of the patients. RESULTS: The 3-year overall survival rate of all patients was 55.0%. In multivariate analysis, the only significant invasion site for overall survival was the facial nerve, with the dura mater being the next most influential site. When Kaplan-Meier survival curve was calculated, facial nerve and dura mater were the significant factors resulting in poor patient outcomes. CONCLUSION: The facial nerve and dura mater are crucial sites of EAC cancer for patient outcomes.
BACKGROUND: This study aimed to reveal the influence of the invasion site of external auditory canal (EAC) cancer by analyzing the outcome of patients with advanced tumor. METHODS: A total of 111 patients with T4 EAC cancer were enrolled in this study. Of these patients, 79 underwent chemoradiotherapy and 32 underwent surgery under curative intent. Univariate and multivariate analyses and the Kaplan-Meier method were used to focus on the tumor invasion sites and overall survival of the patients. RESULTS: The 3-year overall survival rate of all patients was 55.0%. In multivariate analysis, the only significant invasion site for overall survival was the facial nerve, with the dura mater being the next most influential site. When Kaplan-Meier survival curve was calculated, facial nerve and dura mater were the significant factors resulting in poor patient outcomes. CONCLUSION: The facial nerve and dura mater are crucial sites of EAC cancer for patient outcomes.
Authors: Cindy H Nabuurs; Wietske Kievit; C René Leemans; Conrad F G M Smit; Michiel W M van den Brekel; Robert J Pauw; Bernard F A M van der Laan; Jeroen C Jansen; Martin Lacko; Weibel W Braunius; Chunfu Dai; Xunbei Shi; Giovanni Danesi; Jan Bouček; Robert P Takes; Henricus P M Kunst Journal: Head Neck Date: 2022-05-13 Impact factor: 3.821