Literature DB >> 342401

Differential tolerance of thymus-independent and thymus-dependent antibody responses.

J P Tite, S Marshall-Clarke, J H Playfair.   

Abstract

The effect of pre-immunization with soluble haptenated serum proteins or haptenated carbohydrates on the subsequent responses to the hapten in thymus-dependent or thymus-independent form was investigated. In certain cases both thymus-dependent and -independent responses were suppressed whilst in others a differential suppression of thymus-independent responsiveness was observed. These results are discussed in terms of B-cell subpopulations and mechanisms of tolerance induction.

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Year:  1978        PMID： 342401      PMCID： PMC1457698     

Source DB:  PubMed          Journal:  Immunology        ISSN： 0019-2805            Impact factor:   7.397


  21 in total

1.  Evidence for separate subpopulations of B cells responding to T-independent and T-dependent immunogens.

Authors:  J J Jennings; M B Rittenberg
Journal:  J Immunol       Date:  1976-11       Impact factor: 5.422

2.  Separate thymus dependent and thymus independent antibody forming cell precursors.

Authors:  J H Playfair; E C Purves
Journal:  Nat New Biol       Date:  1971-06-02

3.  B cell tolerance induced by polymeric antigens. II. Effects of tolerance on hapten-binding lymphocyte levels in primary and secondary antibody responses.

Authors:  G G Klaus
Journal:  Eur J Immunol       Date:  1976-06       Impact factor: 5.532

4.  Mechanisms by which hapten conjugates of pneumococcal polysaccharide interfere with the challenge of anti-hapten memory cells.

Authors:  T J Romano; S P Lerman; G J Thorbecke
Journal:  Eur J Immunol       Date:  1976-06       Impact factor: 5.532

5.  B cell tolerance induced by polymeric antigens. I. Comparison of the dose and epitope density requirements for inactivation of primed and unprimed B cells in vivo.

Authors:  G G Klaus; J H Humphrey
Journal:  Eur J Immunol       Date:  1976-06       Impact factor: 5.532

6.  In vitro responses of CBA/N mice: spleen cells of mice with an X-linked defect that precludes immune responses to several thymus-independent antigens can respond to TNP-lipopolysaccharide.

Authors:  D E Mosier; I Scher; W E Paul
Journal:  J Immunol       Date:  1976-10       Impact factor: 5.422

7.  Role of epitope density in the induction of tolerance and immunity with thymus-independent antigens. III. Interaction of epitope density and receptor avidity.

Authors:  C Desaymard; B Pearce; M Feldmann
Journal:  Eur J Immunol       Date:  1976-09       Impact factor: 5.532

8.  The relationship between antigenic structure and the requirement for thymus-derived cells in the immune response.

Authors:  M Feldmann; A Easten
Journal:  J Exp Med       Date:  1971-07-01       Impact factor: 14.307

9.  Cellular requirements for the primary in vitro antibody response to DNP-ficoll.

Authors:  D E Mosier; B M Johnson; W E Paul; P R McMaster
Journal:  J Exp Med       Date:  1974-05-01       Impact factor: 14.307

10.  Overlap stimulation of primary and secondary B cells by cross-reacting determinants.

Authors:  N R Klinman; J L Press; G P Segal
Journal:  J Exp Med       Date:  1973-11-01       Impact factor: 14.307
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  7 in total

1.  Cyclosporin A has differential effects on the responses of murine B cells to TI antigens and B-cell mitogens.

Authors:  A D Higham; R A Sells; S Marshall-Clarke
Journal:  Immunology       Date:  1986-10       Impact factor: 7.397

2.  Immunoregulation by covalent antigen-antibody complexes. II. Suppression of a T-cell independent anti-hapten response.

Authors:  J P Tite; R B Taylor
Journal:  Immunology       Date:  1979-10       Impact factor: 7.397

3.  Time-dependence and selectivity of immunosuppressive agents.

Authors:  M C Berenbaum
Journal:  Immunology       Date:  1979-02       Impact factor: 7.397

4.  The expression of surface IgD on B cells responsive to thymus-independent and thymus-dependent antigens and its requirement for B-cell triggering.

Authors:  S Marshall-Clarke; K D Keeler; M E Parkhouse
Journal:  Immunology       Date:  1983-02       Impact factor: 7.397

5.  B-cell subsets responsive to fluorescein-conjugated antigens. III. Differential effect of E. Coli lipopolysaccharide on T-dependent and T-independent responses in vivo.

Authors:  M Venkataraman; D W Scott
Journal:  Immunology       Date:  1979-11       Impact factor: 7.397

6.  Immunoregulatory effects of covalent antigen-antibody complexes. III. Enhancement or suppression depending on the time of administration of complex relative to a T-independent antigen.

Authors:  J P Tite; C A Morrison; R B Taylor
Journal:  Immunology       Date:  1981-02       Impact factor: 7.397

7.  Definition of conditions that enable antigen-specific activation of the majority of isolated trinitrophenol-binding B cells.

Authors:  J C Cambier; J G Monroe; M J Neale
Journal:  J Exp Med       Date:  1982-12-01       Impact factor: 14.307
  7 in total

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