Sandra Salas Garcia1, Belén Valcarcel Ruescas2, Mercedes Aristoy Zabaleta3, Sonia León García3, Anna Parra-Llorca4, Juan Diego Toledo5. 1. Neonatology Department, General University Hospital, Castellon, Spain. salas_sangar@gva.es. 2. Department of Pediatrics, Manises Hospital, Valencia, Spain. 3. Neonatology Department, General University Hospital, Castellon, Spain. 4. Neonatal Research Group, Health Research Institute La Fe University and Polytechnic Hospital La Fe, Valencia, Spain. 5. Neonatology Department, University and Polytechnic Hospital La Fe, Valencia, Spain.
Abstract
OBJECTIVE: Early onset sepsis (EOS) remains a serious and potentially fatal illness. We aimed to demonstrate that serial clinical observation (SCO) is a feasible strategy associated with fewer laboratory evaluations and unnecessary antibiotic use. STUDY DESIGN: We compared the admissions and antibiotic therapy in neonates ≥35 weeks' gestation at risk for EOS in a prospective cohort after the implementation of a new protocol based on SCO (n = 381) with a historical cohort which received laboratory testing (n = 417). RESULTS: There was a significant reduction in admissions for suspected sepsis (7.2% vs 2.9%, p = 0.006) and the use of antibiotics (6.1% vs 0.7%, p = 0.000) in the cohort based on SCO. There was no delay in diagnosis. CONCLUSIONS: SCO in neonates ≥35 weeks' gestation at risk for EOS, including chorioamnionitis-exposed infants, is a feasible measure that reduces laboratory evaluations and the overuse of antibiotics respecting the bonding mother-infant.
OBJECTIVE: Early onset sepsis (EOS) remains a serious and potentially fatal illness. We aimed to demonstrate that serial clinical observation (SCO) is a feasible strategy associated with fewer laboratory evaluations and unnecessary antibiotic use. STUDY DESIGN: We compared the admissions and antibiotic therapy in neonates ≥35 weeks' gestation at risk for EOS in a prospective cohort after the implementation of a new protocol based on SCO (n = 381) with a historical cohort which received laboratory testing (n = 417). RESULTS: There was a significant reduction in admissions for suspected sepsis (7.2% vs 2.9%, p = 0.006) and the use of antibiotics (6.1% vs 0.7%, p = 0.000) in the cohort based on SCO. There was no delay in diagnosis. CONCLUSIONS: SCO in neonates ≥35 weeks' gestation at risk for EOS, including chorioamnionitis-exposed infants, is a feasible measure that reduces laboratory evaluations and the overuse of antibiotics respecting the bonding mother-infant.
Authors: Mary C Ottolini; Kathleen Lundgren; Laura J Mirkinson; Sheila Cason; Martin G Ottolini Journal: Pediatr Infect Dis J Date: 2003-05 Impact factor: 2.129
Authors: Francesco Cavigioli; Francesca Viaroli; Irene Daniele; Michela Paroli; Luigi Guglielmetti; Elena Esposito; Francesco Cerritelli; Gianvincenzo Zuccotti; Gianluca Lista Journal: Antibiotics (Basel) Date: 2022-08-11