Literature DB >> 34238011

Management of Congenital Long-QT Syndrome: Commentary From the Experts.

Lee L Eckhardt1, Elizabeth S Kaufman2, Michael J Ackerman3,4,5, Peter F Aziz6, Elijah R Behr7,8, Marina Cerrone9, Mina K Chung10, Michael J Cutler11, Susan P Etheridge12, Andrew D Krahn13, Steven A Lubitz14, Marco V Perez15, Silvia G Priori8,16,17, Jason D Roberts18, Dan M Roden19, Eric Schulze-Bahr8,20, Peter J Schwartz8,21, Wataru Shimizu22, M Benjamin Shoemaker23, Raymond W Sy24,25, Jeffrey A Towbin26, Sami Viskin27, Arthur A M Wilde8,28,29, Wojciech Zareba30.   

Abstract

While published guidelines are useful in the care of patients with long-QT syndrome, it can be difficult to decide how to apply the guidelines to individual patients, particularly those with intermediate risk. We explored the diversity of opinion among 24 clinicians with expertise in long-QT syndrome. Experts from various regions and institutions were presented with 4 challenging clinical scenarios and asked to provide commentary emphasizing why they would make their treatment recommendations. All 24 authors were asked to vote on case-specific questions so as to demonstrate the degree of consensus or divergence of opinion. Of 24 authors, 23 voted and 1 abstained. Details of voting results with commentary are presented. There was consensus on several key points, particularly on the importance of the diagnostic evaluation and of β-blocker use. There was diversity of opinion about the appropriate use of other therapeutic measures in intermediate-risk individuals. Significant gaps in knowledge were identified.

Entities:  

Keywords:  defibrillators, implantable; genetic testing; knowledge; long-QT syndrome; politics

Mesh:

Substances:

Year:  2021        PMID: 34238011      PMCID: PMC8301722          DOI: 10.1161/CIRCEP.120.009726

Source DB:  PubMed          Journal:  Circ Arrhythm Electrophysiol        ISSN: 1941-3084


  48 in total

1.  Clinical implications for affected parents and siblings of probands with long-QT syndrome.

Authors:  J Kimbrough; A J Moss; W Zareba; J L Robinson; W J Hall; J Benhorin; E H Locati; A Medina; C Napolitano; S Priori; P J Schwartz; K Timothy; J A Towbin; G M Vincent; L Zhang
Journal:  Circulation       Date:  2001-07-31       Impact factor: 29.690

Review 2.  HRS/EHRA/APHRS expert consensus statement on the diagnosis and management of patients with inherited primary arrhythmia syndromes: document endorsed by HRS, EHRA, and APHRS in May 2013 and by ACCF, AHA, PACES, and AEPC in June 2013.

Authors:  Silvia G Priori; Arthur A Wilde; Minoru Horie; Yongkeun Cho; Elijah R Behr; Charles Berul; Nico Blom; Josep Brugada; Chern-En Chiang; Heikki Huikuri; Prince Kannankeril; Andrew Krahn; Antoine Leenhardt; Arthur Moss; Peter J Schwartz; Wataru Shimizu; Gordon Tomaselli; Cynthia Tracy
Journal:  Heart Rhythm       Date:  2013-08-30       Impact factor: 6.343

3.  Risk of cardiac events in patients with asthma and long-QT syndrome treated with beta(2) agonists.

Authors:  Princy Thottathil; Jay Acharya; Arthur J Moss; Christian Jons; Scott McNitt; Ilan Goldenberg; Wojciech Zareba; Elizabeth Kaufman; Ming Qi; Jennifer L Robinson
Journal:  Am J Cardiol       Date:  2008-07-17       Impact factor: 2.778

Review 4.  Beta-blocker therapy for long QT syndrome and catecholaminergic polymorphic ventricular tachycardia: Are all beta-blockers equivalent?

Authors:  Michael J Ackerman; Silvia G Priori; Anne M Dubin; Peter Kowey; Nicholas J Linker; David Slotwiner; John Triedman; George F Van Hare; Michael R Gold
Journal:  Heart Rhythm       Date:  2016-09-19       Impact factor: 6.343

5.  Grapefruit juice prolongs the QT interval of healthy volunteers and patients with long QT syndrome.

Authors:  Ehud Chorin; Aviram Hochstadt; Yoav Granot; Shafik Khoury; Arie Lorin Schwartz; Gilad Margolis; Rami Barashi; Dana Viskin; Eihab Ghantous; Michael Schnapper; Tal Mekori; Dana Fourey; Milton Ernesto Guevara-Valdivia; Manlio F Marquez; David Zeltzer; Raphael Rosso; Sami Viskin
Journal:  Heart Rhythm       Date:  2019-05-08       Impact factor: 6.343

6.  Effectiveness and limitations of beta-blocker therapy in congenital long-QT syndrome.

Authors:  A J Moss; W Zareba; W J Hall; P J Schwartz; R S Crampton; J Benhorin; G M Vincent; E H Locati; S G Priori; C Napolitano; A Medina; L Zhang; J L Robinson; K Timothy; J A Towbin; M L Andrews
Journal:  Circulation       Date:  2000-02-15       Impact factor: 29.690

7.  Identification of a common genetic substrate underlying postpartum cardiac events in congenital long QT syndrome.

Authors:  Anant Khositseth; David J Tester; Melissa L Will; Carla M Bell; Michael J Ackerman
Journal:  Heart Rhythm       Date:  2004-05       Impact factor: 6.343

8.  ECG T-wave patterns in genetically distinct forms of the hereditary long QT syndrome.

Authors:  A J Moss; W Zareba; J Benhorin; E H Locati; W J Hall; J L Robinson; P J Schwartz; J A Towbin; G M Vincent; M H Lehmann
Journal:  Circulation       Date:  1995-11-15       Impact factor: 29.690

9.  Risk stratification in the long-QT syndrome.

Authors:  Silvia G Priori; Peter J Schwartz; Carlo Napolitano; Raffaella Bloise; Elena Ronchetti; Massimiliano Grillo; Alessandro Vicentini; Carla Spazzolini; Janni Nastoli; Georgia Bottelli; Roberta Folli; Donata Cappelletti
Journal:  N Engl J Med       Date:  2003-05-08       Impact factor: 91.245

10.  Exercise Training-Induced Repolarization Abnormalities Masquerading as Congenital Long QT Syndrome.

Authors:  Federica Dagradi; Carla Spazzolini; Silvia Castelletti; Matteo Pedrazzini; Maria-Christina Kotta; Lia Crotti; Peter J Schwartz
Journal:  Circulation       Date:  2020-10-19       Impact factor: 29.690

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