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Literature DB >> 342358

Can hepatic coma be caused by a reduction of brain noradrenaline or dopamine?

Abstract

Intraventricular infusions of octopamine which raised brain octopamine concentrations more than 20 000-fold resulted in reductions in brain noradrenaline and dopamine by as much as 90% without affecting the alertness or activity of normal rats. As this reduction of brain catecholamines is much greater than any reported in hepatic coma, we do not believe that values observed in experimental hepatic failure have aetiological significance for the encephalopathy that ensues.

Entities: Chemical Disease Species

Mesh：

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Year: 1977 PMID： 342358 PMCID： PMC1411646 DOI： 10.1136/gut.18.9.688

Source DB: PubMed Journal: Gut ISSN： 0017-5749 Impact factor: 23.059

13 in total

1. Letter: Neurotransmitter metabolism in hepatic encephalopathy.

Authors: J E Fischer; R J Baldessarini
Journal: N Engl J Med Date: 1975-11-27 Impact factor: 91.245

2. Enzymatic-isotopic method for octopamine at the picogram level.

Authors: J M Saavedra
Journal: Anal Biochem Date: 1974-06 Impact factor: 3.365

3. Depletion of brain norepinephrine in acute hepatic coma.

Authors: J M Dodsworth; J H James; M C Cummings; J F Fischer
Journal: Surgery Date: 1974-06 Impact factor: 3.982

4. Role of a false neurotransmitter, octopamine, in the pathogenesis of hepatic and renal encephalopathy.

Authors: K C Lam; A R Tall; G B Goldstein; S P Mistilis
Journal: Scand J Gastroenterol Date: 1973 Impact factor: 2.423

5. Synaptic biochemistry of amino acids.

Authors: S H Snyder; A B Young; J P Bennett; A H Mulder
Journal: Fed Proc Date: 1973-10

6. Increased fixed-ratio performance and differential d- and l-amphetamine action following norepinephrine depletion by intraventricular 6-hydroxydopamine.

Authors: D W Peterson; S B Sparber
Journal: J Pharmacol Exp Ther Date: 1974-12 Impact factor: 4.030

6. Brain tyrosine hydroxylase activity and calculated amount of brain dopa synthesized in carbon tetrachloride-intoxicated rats.

Authors: N Takei; A Watanabe; T Sakata; S Hayashi; T Obata; T Shiota; H Nagashima
Journal: Gastroenterol Jpn Date: 1983-02

Can hepatic coma be caused by a reduction of brain noradrenaline or dopamine?

1. Letter: Neurotransmitter metabolism in hepatic encephalopathy.

2. Enzymatic-isotopic method for octopamine at the picogram level.

3. Depletion of brain norepinephrine in acute hepatic coma.

4. Role of a false neurotransmitter, octopamine, in the pathogenesis of hepatic and renal encephalopathy.

5. Synaptic biochemistry of amino acids.

6. Increased fixed-ratio performance and differential d- and l-amphetamine action following norepinephrine depletion by intraventricular 6-hydroxydopamine.

7. Synergism between ammonia and fatty acids in the production of coma: implications for hepatic coma.

8. False neurotransmitters and hepatic failure.

9. Urinary and serum octopamine in patients with portal-systemic encephalopathy.

10. Insulin, plasma aminoacid imbalance, and hepatic coma.

Review 1. Hepatic encephalopathy in liver cirrhosis: pathogenesis, diagnosis and management.

2. Controversies in ammonia metabolism: implications for hepatic encephalopathy.

Review 3. Interrelationships of liver and brain with special reference to Reye syndrome.

Review 4. Branched chain amino acids in liver disease: fact or fantasy?

Review 5. Some clinical features of liver cell failure: an appraisal of their causes.

6. Brain tyrosine hydroxylase activity and calculated amount of brain dopa synthesized in carbon tetrachloride-intoxicated rats.

7. Amino acids in hepatic coma.

Review 8. Pathogenesis of hepatic encephalopathy.

9. Blood and brain concentrations of mercaptans in hepatic and methanethiol induced coma.

10. Reversal of ammonia coma in rats by L-dopa: a peripheral effect.