Overcoming Diagnostic Dilemma and Optimizing Intervention with Optical Coherence Tomographic Guidance in an Angiographically Ambiguous Renal Artery Stenosis Due to Fibromuscular Dysplasia.

With the advent of endovascular therapy, conventional angiography has replaced histology as a diagnostic gold standard for fibromuscular dysplasia (FMD). However, angiographic findings are not precisely diagnostic in isolated focal renal artery stenosis (RAS) in FMD. Optical coherence tomography (OCT) imaging by reflecting in vivo histology may improve the diagnostic accuracy in such cases. Restenosis following balloon angioplasty of RAS in FMD occurs frequently and often requires optimized reintervention. However, the role of OCT in the diagnostic evaluation of focal RAS in FMD and in optimizing the intervention is not well studied. We present a young female with resistant secondary hypertension due to bilateral focal RAS on angiography. In the absence of an angiographic string of beads appearance, the diagnoses remained uncertain. However, OCT imaging diagnosed a multifocal disease with characteristic changes of fibro-medial dysplasia, akin to its histological description in the literature. The patient underwent bilateral balloon angioplasty with good angiographic results. After one year on follow-up, relapse of uncontrolled systemic hypertension occurred due to bilateral restenosis. Despite a satisfactory repeat balloon angioplasty of the left-sided re-stenotic lesion, a significant residual pressure gradient persisted. Usage of OCT guided oversized balloon and stent safely achieved good results with complete resolution of the pressure gradient. Right renal artery stenosis required balloon angioplasty alone. She had complete resolution of hypertension without any medications at six months of follow-up. In conclusion, OCT can supplement other diagnostic modalities in providing a proper diagnosis in an angiographically ambiguous focal RAS in FMD. A persistent residual pressure gradient across the lesion despite good angiographic results may be optimized with OCT guidance during the intervention.

Introduction

Fibromuscular dysplasia (FMD) is an uncommon cause of secondary hypertension due to associated renal artery stenosis (RAS), which usually is bilateral.1 Although angiography is considered a gold standard for diagnosis and classification of FMD but has some limitations in the characterization of vessel wall and classification of disease, which can be overcome with Optical Coherence Tomography (OCT).2 When associated with resistant hypertension, renal angioplasty is indicated.1,3 However, in contrast to atherosclerotic disease, balloon angioplasty rather than stenting is a preferred strategy.1,3,4 Outcome following revascularization is variable, and on average, only 36% achieve cure of hypertension.5 Younger age and shorter duration of hypertension correlate with increased likelihood of resolution of hypertension.1,3,6 Focal disease has been shown to fare better in terms of outcome than the multifocal disease. Finally, the rate of reintervention after balloon angioplasty remains high, around 28% at five years.3,6

We report a young female with resistant hypertension secondary to bilateral RAS due to FMD, where OCT characterization helped in the diagnosis and proper classification of an angiographically ambiguous focal stenosis. She underwent successful OCT guided balloon angioplasty to bilateral renal arteries with reasonable control of her blood pressure. However, one year after the intervention, she had a relapse of uncontrolled hypertension due to bilateral restenosis requiring re-intervention. OCT guidance during re-intervention encouraged the use of an oversized stent for residual translesional pressure gradient with excellent angiographic, tomographic and clinical outcome.

Case Presentation

History dates back to 3 years back when she was detected to be hypertensive during pregnancy and prescribed labetalol, amlodipine and hydrochlorothiazide. One and half years later, at the age of 30 years, she presented to us with complaints of dyspnea and headache for last six months. She also has a history of hospitalization for pulmonary edema 15 days before that presentation. Her clinical examination was inconspicuous except for high blood pressure of 210/120 mmHg. In addition to previous medications, clonidine and prazosin were added to control her blood pressure.

Her biochemical profile, including serum creatinine (0.8mg/dL) and estimated Glomerular Filtration Rate (103 mL/min), was normal. Abdominal ultrasound showed bilateral normal-sized kidneys with preserved cortico-medullary differentiation. Electrocardiogram was suggestive of left ventricular hypertrophy, and echocardiography revealed a left ventricular ejection fraction (LVEF) of 45%. Renal artery Doppler suspected bilateral renal artery stenosis (RAS). Contrast-enhanced Computed Tomography (CT) (Figure 1A) and conventional angiography (Figure 1B and C) showed critical focal stenosis in the mid-segment of the bilateral main renal arteries, which in a young female, although suggestive but is not diagnostic of FMD. No string of beads appearance typical of FMD was observed.

Figure 1

Various Imaging modalities used in diagnosing Renal artery stenosis in fibromuscular dysplasia.

To help diagnose and rule out other differentials, Optical Coherence Tomography (OCT) imaging was performed before intervention by the frequency-domain system (ILUMIEN TM Optis System using Dragonfly Optis Catheter TM St. Jude Medical, MA, USA). This is a US FDA approved modality for use in peripheral arteries. OCT imaging of the left renal artery revealed a characteristic string of beads appearance in longitudinal reconstruction (Figure 1D). Cross-sectional images show an intima-media dissection (Figure 1E) and homogeneously thickened media as a low backscatter layer with a high backscatter in the inner half suggestive of fibrosis. These features are characteristic of predominantly medial fibroplasia type of FMD. OCT quantified luminal area stenosis to 92% (Figure 1F) with a normal reference segment (Figure 1G). OCT of the right renal artery (done after balloon) angioplasty revealed a homogeneously thickened media with minimal fibrosis suggestive of medial fibroplasia (Figure 1H).

Due to resistant hypertension, she was offered renal angioplasty, which she accepted. As OCT measured distal reference diameter was 4.1 mm, the left and right RAS was dilated with a 4mmx12mm semi-compliant balloon with good angiographic and tomographic (OCT) results. A translesional pressure gradient was not measured. Blood pressure normalized immediately after the procedure, and she was discharged on 20 mg telmisartan because of left ventricular dysfunction/hypertrophy and aspirin 75 mg daily. After one year of follow-up, she gradually started having a recurrence of headache and dyspnea. Home measurements revealed multiple blood pressure recordings of >180/90 requiring escalation of anti-hypertensives. A repeat renal Doppler was suggestive of bilateral renal artery stenosis, and a renal artery angiography revealed 90% bilateral focal restenosis at the previous sites (Figure 2A and B). OCT of the left renal artery revealed focal stenosis with homogeneously thickened media with fibrosis in the inner half, as on the initial imaging (Figure 2C–F). No dissection flap was seen this time. The distal reference vessel was 4.2 mm. OCT of the right renal artery was suggestive of medial fibroplasia as before, with the distal reference diameter of 4.0 mm.

Figure 2

Current bilateral renal angiogram showing significant restenosis (arrows) in the left (A) and right (B) renal arteries. Longitudinal reconstruction of optical coherence tomography (OCT) imaging (C) of left renal artery depicting the corresponding lesion indicated by white arrows. Cross-sectional images showing distal (D) and proximal (F) reference zones are free of disease and measure 4.2mm. The area of focal restenosis on the angiogram correlate with extensive medial and intimal hyperplasia (arrows) on OCT (E), causing 87% area (re) stenosis.

Subsequently, after initial balloon angioplasty with a 4.0mm and then a 4.5×12 mm balloon, a pressure gradient of 15 mmHg was noticed across the lesion in the left renal artery. Further dilation with a 5×10 mm balloon followed by stenting with a 5mm x 15 mm renal stent system (RX Herculink Elite stent, Abbott Vascular, Abbott Park, IL) lead to resolution of pressure gradient across the lesion on the left side. The decision to stent the lesion was taken due to the presence of restenosis and residual gradient. Angiographic and OCT imaging confirmed good stent expansion and apposition (Figure 3A–E). On the right side, there was no pressure gradient after balloon angioplasty with a 4.5 mm balloon, so stenting was not performed (Figure 3C and F). At six months follow-up after the reintervention, she remains normotensive without any medications. Currently, she is on aspirin 75mg daily.

Figure 3

Angiogram showing stent deployment in the left renal artery (A) with an excellent angiographic result (B). The right renal artery shows (C) a good result with balloon angioplasty alone. Longitudinal (D) and cross-sectional (E) OCT images of left renal artery show good stent expansion and apposition (arrows) without residual stenosis. Cross-sectional OCT image (F) of right renal artery after balloon angioplasty shows good result with some intimal tears (arrows) and no residual stenosis (correlate with Image (C)).

Discussion

FMD is a rare, idiopathic, non-inflammatory, non-atherosclerotic condition, which usually involves small and medium-sized arteries. Renal artery involvement is common, frequently bilateral, usually presents with hypertension, and significantly increases the risk of preeclampsia in women of childbearing age.7 Originally classified histologically by Harrison & McCormack based on the layer of the artery predominately involved,8 medial fibroplasia and peri-medial fibroplasia with characteristics string of beads appearance account for is 75–80% and 10–15% of cases whereas medial hyperplasia and intimal fibroplasia with angiographic focal, concentric stenosis, account for 1–2%, and <10% of cases respectively. Adventitial type is the least common (<1%) lesion with sharply localized, tubular areas of stenosis.9 In the current era of endovascular therapy, surgical specimens are rarely available for histological examination. So FMD was later adapted to angiographic classification through histological-angiographic correlation.1 American Heart Association consensus document (2014) classified FMD angiographically into focal and multifocal types. Multifocal FMD with a ‘string of beads’ appearance is the most common type (80–90%), usually involves mid and distal portions of the artery, and is represented by medial fibroplasia virtually in all adults. On the other hand, focal FMD may occur in any part of the renal artery and is usually caused by intimal fibroplasia or sometimes by medial hyperplasia or adventitial type.3 The majority of patients with a multifocal variant have a typical presentation of renal FMD as a middle-aged woman with hypertension, whereas focal FMD patients are usually <30 years with an average BP higher than the multifocal variant.10

Catheter-based angiography, a gold standard for diagnosing FMD,7 is superior to other imaging modalities and offers an opportunity for endovascular therapy.11 Albeit angiographic multifocal stenosis is typical of FMD, yet focal stenosis requires further evaluation. In such a situation, OCT imaging appears to be more promising for diagnosing and classifying FMD, at least in a medium-sized renal artery. As FMD commonly involves intima and media, high resolution of OCT allows easy assessment of morphology, vascular characteristics, and differentiation from other causes of RAS. OCT imaging in our case reclassified angiographically focal lesion as medial fibroplasia with a characteristic beaded appearance of multifocal disease, which was not discernible on conventional angiography.

Limited data focusing on the systematic role of OCT in the diagnosis and classification of FMD is available. In addition to illustrating the benefits of OCT in diagnosis and intervention in RAS in FMD as reported by Mizutani et al,2 our case additionally explores the utility of OCT in correctly classifying the type of FMD in the angiographically ambiguous lesion. Proper classification of FMD could have prognostic implications as hypertension cure rate after interventions could be better in focal versus the multifocal type of FMD.12 Accordingly, we contemplate the characterization with OCT in guiding the classification of FMD, especially in angiographic focal or ambiguous disease. However, as the existing literature on the use of OCT to diagnose renal FMD is limited to a few case reports, the diagnostic accuracy of OCT for renal FMD and its ability to differentiate from atherosclerosis needs to be demonstrated in larger studies. Also, the correlation between OCT findings and histology in the diagnosis of FMD requires validation.

Revascularization is indicated in patients with resistant hypertension, intolerance or non-compliance to medication, and progressive renal dysfunction. Over the years, endovascular intervention has replaced traditional surgical repair as the first-line therapy.1,3 In general, balloon angioplasty is the treatment of choice. Stenting is reserved for lesions with suboptimal results after balloon angioplasty. However, high recurrence rates of around 28% at five years have been reported.6 As a result, many have advocated an upfront stenting strategy to avoid restenosis and repeat interventions.13,14 Stenting is best avoided in distal renal arteries and smaller renal arteries because of the higher restenosis rate.3,4,6 For balloon angioplasty, the semi-compliant balloon is sized 1:1 to the reference vessel diameter. The non-compliant or cutting balloon is usually avoided for the risk of rupture. Despite good angiographic appearance after balloon angioplasty, the results may be suboptimal as in our case. The usual approach in such a case is to gradually increase the balloon size until the translesional gradient resolves. Nevertheless, it carries the risk of vascular injuries like rupture or dissection,3 significantly if device size far exceeds the vessel size. Measuring the vessel size with intravascular imaging like OCT may guide correct selection of balloon/stent size. In the index case, though the vessel was 4.1 mm, we could confidently use a 5 mm stent with OCT guidance, which resolved the translesional gradient with minimal risk of any complication. However, angiographic appearance alone should not be used as a surrogate for successful intervention. Measurement of the pressure gradient is also essential to confirm the procedural success.15 The persistent residual gradient may be due to inadequate lesion dilatation, recoil, or a dissection flap which may require a stent. In the index case, we had an excellent angiographic and OCT outcome during the first intervention; however, the translesional gradient was not measured. During the subsequent intervention for restenosis, a persistent residual pressure gradient despite good angiographic results after balloon angioplasty required stenting. For this, OCT guidance was indispensable in choosing the stent size and achieving a complete resolution of the translesional pressure gradient.

Due to its higher resolution than intravascular ultrasound (IVUS), OCT is ideally suited for assessing the intima and media of the vessels.16 However, it has poor penetration limits visualization of distant structures.17 Another problem is the difficulty in obtaining clearance of blood for OCT imaging in large arteries. In the index case, although with difficulty, we were able to achieve good blood clearance and OCT images of FMD of the renal arteries.

In conclusion, virtual histology on OCT imaging aids in confirming the diagnosis in angiographically ambiguous focal disease. Further, in addition to understanding the mechanism of restenosis, OCT imaging may add safety in selecting balloon/stent size and optimize the intervention. Good angiographic results should always be supplemented with pressure gradient measurement to confirm technical success. Residual gradient after balloon angioplasty may require stenting, especially in the case of restenosis. Further research is warranted to know additional factors that predispose to restenosis, and an upfront stenting strategy may be beneficial in such circumstances.