| Literature DB >> 3423424 |
B J Cusack1, D A Tesnohlidek, V L Loseke, R M Eggerth, R D Olson.
Abstract
Phenytoin pharmacokinetics were studied during continuous intravenous infusion in 12 New Zealand white rabbits. The mean clearance at 40 hours (5.1 +/- 1.1 ml/min per kg; mean +/- SE) was significantly greater than that at 16 hours (3.1 +/- 0.5 ml/min per kg; p less than 0.05). These data suggest that with chronic administration, autoinduction of metabolism results in an increase in the rate of phenytoin clearance in the rabbit.Entities:
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Year: 1987 PMID： 3423424
Source DB: PubMed Journal: Res Commun Chem Pathol Pharmacol ISSN： 0034-5164