| Literature DB >> 34233574 |
Hideaki Morishita1,2, Tomoya Eguchi1, Noboru Mizushima1.
Abstract
All membrane-bound organelles are degraded during the terminal differentiation of lens fiber cells. How these organelles are degraded has been a long-standing question in biology. We recently revealed that PLAAT (phospholipase A and acyltransferase)-family phospholipases degrade organelles in the lens independently of macroautophagy. Here, we discuss the mechanism and physiological relevance of this new mode of intracellular degradation.Entities:
Keywords: Autophagy; HRASLS; PLA2G16; PLAAT; lens; mice; organelle degradation; phospholipase; zebrafish
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Year: 2021 PMID： 34233574 PMCID： PMC8496548 DOI： 10.1080/15548627.2021.1950372
Source DB: PubMed Journal: Autophagy ISSN： 1554-8627 Impact factor: 13.391