Kimberly M Albert1, Brian D Boyd2, Warren D Taylor3, Paul A Newhouse3. 1. Center for Cognitive Medicine, Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN, United States. Electronic address: kimberly.albert@vumc.org. 2. Center for Cognitive Medicine, Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN, United States. 3. Center for Cognitive Medicine, Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN, United States; Geriatric Research, Education, and Clinical Center, Tennessee Valley VA Health System, Nashville TN, United States.
Abstract
BACKGROUND: Estrogen fluctuations throughout the lifespan may contribute to major depressive disorder (MDD) risk in women through effects on brain networks important in stress responding, and mood regulation. Although there is evidence to support ovarian hormone treatment for peri-menopausal depression, postmenopausal use has not been well examined. The objective of this study was to investigate whether estrogen modulation of the neural and emotional cognitive responses to stress differs between postmenopausal women with and without MDD history. METHODS: 60 postmenopausal women completed an fMRI psychosocial stress task, after receiving no drug or 3 months of daily estradiol (E2). fMRI activity and subjective mood response were examined. RESULTS: In women without a history of MDD, E2 was associated with a more negative mood response to stress and less activity in emotional regulation regions. In women with a history of MDD, E2 was associated with a less negative mood response to stress and less activity in emotion perception regions. LIMITATIONS: This study was limited by open-label estradiol administration and inclusion of participants using antidepressants. CONCLUSIONS: These results support a differential effect of estrogen on emotional and neural responses to psychosocial stress in postmenopausal women with MDD history and may reflect a shift in brain activity patterns related to emotion processing following menopause.
BACKGROUND: Estrogen fluctuations throughout the lifespan may contribute to major depressive disorder (MDD) risk in women through effects on brain networks important in stress responding, and mood regulation. Although there is evidence to support ovarian hormone treatment for peri-menopausal depression, postmenopausal use has not been well examined. The objective of this study was to investigate whether estrogen modulation of the neural and emotional cognitive responses to stress differs between postmenopausal women with and without MDD history. METHODS: 60 postmenopausal women completed an fMRI psychosocial stress task, after receiving no drug or 3 months of daily estradiol (E2). fMRI activity and subjective mood response were examined. RESULTS: In women without a history of MDD, E2 was associated with a more negative mood response to stress and less activity in emotional regulation regions. In women with a history of MDD, E2 was associated with a less negative mood response to stress and less activity in emotion perception regions. LIMITATIONS: This study was limited by open-label estradiol administration and inclusion of participants using antidepressants. CONCLUSIONS: These results support a differential effect of estrogen on emotional and neural responses to psychosocial stress in postmenopausal women with MDD history and may reflect a shift in brain activity patterns related to emotion processing following menopause.
Authors: Benicio N Frey; Geoffrey B Hall; Stefanie Attard; Kaan Yucel; Ivan Skelin; Meir Steiner; Claudio N Soares Journal: Menopause Date: 2010-07 Impact factor: 2.953
Authors: Paul A Newhouse; Julie Dumas; Catherine Hancur-Bucci; Magdalena Naylor; Cynthia K Sites; Chawki Benkelfat; Simon N Young Journal: Neuropsychopharmacology Date: 2007-08-15 Impact factor: 7.853
Authors: Evelyn Bromet; Laura Helena Andrade; Irving Hwang; Nancy A Sampson; Jordi Alonso; Giovanni de Girolamo; Ron de Graaf; Koen Demyttenaere; Chiyi Hu; Noboru Iwata; Aimee N Karam; Jagdish Kaur; Stanislav Kostyuchenko; Jean-Pierre Lépine; Daphna Levinson; Herbert Matschinger; Maria Elena Medina Mora; Mark Oakley Browne; Jose Posada-Villa; Maria Carmen Viana; David R Williams; Ronald C Kessler Journal: BMC Med Date: 2011-07-26 Impact factor: 8.775