| Literature DB >> 34233171 |
Sally Winther1, Mette Trauelsen1, Thue W Schwartz2.
Abstract
The TCA cycle metabolite succinate functions as an intra- and extracellular signal of metabolic stress. Based on the phenotype of UCP-1-deficient mice, Mills et al. (2021) now report in Nature Metabolism that accumulation of extracellular succinate due to impaired elimination in thermogenic fat drives liver inflammation and fibrosis through the succinate receptor SUCNR1.Entities:
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Year: 2021 PMID： 34233171 DOI： 10.1016/j.cmet.2021.06.009
Source DB: PubMed Journal: Cell Metab ISSN： 1550-4131 Impact factor: 27.287