| Literature DB >> 34231390 |
L K Metthew Lam1,2, John P Reilly1,2, Ann H Rux3, Sophia J Murphy1, Leticia Kuri-Cervantes4,5, Ariel R Weisman1, Caroline A G Ittner1, M Betina Pampena4,5, Michael R Betts4,5, E John Wherry5,6,7, Wen-Chao Song5,6, John D Lambris3, Nuala J Meyer1,2,5,8, Douglas B Cines2,3,5, Nilam S Mangalmurti1,2,5,8.
Abstract
COVID-19, the disease caused by the SARS-CoV-2 virus, can progress to multisystem organ failure and viral sepsis characterized by respiratory failure, arrhythmias, thromboembolic complications, and shock with high mortality. Autopsy and preclinical evidence implicate aberrant complement activation in endothelial injury and organ failure. Erythrocytes express complement receptors and are capable of binding immune complexes; therefore, we investigated complement activation in patients with COVID-19 using erythrocytes as a tool to diagnose complement activation. We discovered enhanced C3b and C4d deposition on erythrocytes in COVID-19 sepsis patients and non-COVID sepsis patients compared with healthy controls, supporting the role of complement in sepsis-associated organ injury. Our data suggest that erythrocytes may contribute to a precision medicine approach to sepsis and have diagnostic value in monitoring complement dysregulation in COVID-19-sepsis and non-COVID sepsis and identifying patients who may benefit from complement targeted therapies.Entities:
Keywords: COVID-19; SARS-CoV-2; complement; erythrocyte; sepsis
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Year: 2021 PMID： 34231390 PMCID： PMC8384475 DOI： 10.1152/ajplung.00231.2021
Source DB: PubMed Journal: Am J Physiol Lung Cell Mol Physiol ISSN： 1040-0605 Impact factor: 6.011