Marwa F Ismail1, Gideon M Hirschfield2, Bettina Hansen1, Monica Tafur3,4, Khaled Y Elbanna3, Marc H Goldfinger5, Gerard R Ridgway5, Kartik S Jhaveri6. 1. Toronto Centre for Liver Disease, University Health Network, University of Toronto, Institute of Health Policy Management and Evaluation, Toronto, ON, Canada. 2. Toronto Centre for Liver Disease, University Health Network, Mt. Sinai & WCH, University of Toronto, Institute of Health Policy Management and Evaluation, Toronto, ON, Canada. 3. Joint Department of Medical Imaging, University Health Network, Mt. Sinai & WCH, University of Toronto, 610 University Ave, 3-957, Toronto, ON, M5G 2M9, Canada. 4. St. Michael's Hospital, University of Toronto, Toronto, ON, Canada. 5. Perspectum Ltd, Oxford, UK. 6. Joint Department of Medical Imaging, University Health Network, Mt. Sinai & WCH, University of Toronto, 610 University Ave, 3-957, Toronto, ON, M5G 2M9, Canada. Kartik.Jhaveri@uhn.ca.
Abstract
OBJECTIVES: To study the association of MRCP+ parameters with biochemical scoring systems and MR elastography (MRE) in primary sclerosing cholangitis (PSC). To evaluate the incremental value of combining MRCP+ with morphological scores in associating with biochemical scores. METHODS AND MATERIALS: MRI images, liver stiffness measurements by MRE, and biochemical testing of 65 patients with PSC that were retrospectively enrolled between January 2014 and December 2015 were obtained. MRCP+ was used to post-process MRCP images to obtain quantitative measurements of the bile ducts and biliary tree. Linear regression analysis was used to test the associations. Bootstrapping was used as a validation method. RESULTS: The total number of segmental strictures had the strongest association with Mayo Risk Score (R2 = 0.14), minimum stricture diameter had the highest association with Amsterdam Oxford Prognostic Index (R2 = 0.12), and the percentage of duct nodes with width 0-3 mm had the strongest association with PSC Risk Estimate Tool (R2 = 0.09). The presence of Ducts with medians > 9 mm had the highest association with MRE (R2= 0.21). The strength of association of MRCP+ to Mayo Risk Score was similar to ANALI2 and weaker than MRE (R2 = 0.23, 0.24, 0.38 respectively). MRCP+ enhanced the association of ANALI 2 and MRE with the Mayo Risk Score. CONCLUSIONS: MRCP+ demonstrated a significant association with biochemical scores and MRE. The association of MRCP+ with the biochemical scores was generally comparable to ANALI scores. MRCP+ enhanced the association of ANALI2 and MRE with the Mayo Risk Score. KEY POINTS: • MRCP+ has the potential to act as a risk stratfier in PSC. • MRE outperformed MRCP+ for risk stratifcation. • Combination of MRCP+ with MRE and ANALI scores improved overall performace as risk stratifiers.
OBJECTIVES: To study the association of MRCP+ parameters with biochemical scoring systems and MR elastography (MRE) in primary sclerosing cholangitis (PSC). To evaluate the incremental value of combining MRCP+ with morphological scores in associating with biochemical scores. METHODS AND MATERIALS: MRI images, liver stiffness measurements by MRE, and biochemical testing of 65 patients with PSC that were retrospectively enrolled between January 2014 and December 2015 were obtained. MRCP+ was used to post-process MRCP images to obtain quantitative measurements of the bile ducts and biliary tree. Linear regression analysis was used to test the associations. Bootstrapping was used as a validation method. RESULTS: The total number of segmental strictures had the strongest association with Mayo Risk Score (R2 = 0.14), minimum stricture diameter had the highest association with Amsterdam Oxford Prognostic Index (R2 = 0.12), and the percentage of duct nodes with width 0-3 mm had the strongest association with PSC Risk Estimate Tool (R2 = 0.09). The presence of Ducts with medians > 9 mm had the highest association with MRE (R2= 0.21). The strength of association of MRCP+ to Mayo Risk Score was similar to ANALI2 and weaker than MRE (R2 = 0.23, 0.24, 0.38 respectively). MRCP+ enhanced the association of ANALI 2 and MRE with the Mayo Risk Score. CONCLUSIONS: MRCP+ demonstrated a significant association with biochemical scores and MRE. The association of MRCP+ with the biochemical scores was generally comparable to ANALI scores. MRCP+ enhanced the association of ANALI2 and MRE with the Mayo Risk Score. KEY POINTS: • MRCP+ has the potential to act as a risk stratfier in PSC. • MRE outperformed MRCP+ for risk stratifcation. • Combination of MRCP+ with MRE and ANALI scores improved overall performace as risk stratifiers.
Authors: Julia Slotta-Huspenina; Konrad Friedrich Stock; Elena Herms; Gregor Weirich; Tobias Maurer; Stefan Wagenpfeil; Stephanie Preuss; Andreas Sauter; Matthias Heck; Anita Gärtner; Katharina Hauner; Michael Autenrieth; Hubert P Kübler; Konstantin Holzapfel; Ulrike Schwarz-Boeger; Uwe Heemann Journal: World J Urol Date: 2022-08-20 Impact factor: 3.661
Authors: Kamil Janowski; Elizabeth Shumbayawonda; Matt Kelly; Carlos Ferreira; Maciej Pronicki; Wieslawa Grajkowska; Magdalena Naorniakowska; Piotr Pawliszak; Sylwia Chełstowska; Elżbieta Jurkiewicz; Rajarshi Banerjee; Piotr Socha Journal: Children (Basel) Date: 2022-04-25