Ricardo Coentre1,2, Alexandra Fonseca3, Tiago Mendes3,4, Ana Rebelo3, Elisabete Fernandes5, Pedro Levy3, Carlos Góis3,4, Maria Luísa Figueira4. 1. Department of Psychiatry, Centro Hospitalar Universitário Lisboa Norte, Av Prof. Egas Moniz, 1649-035, Lisboa, Portugal. ricardomcoentre@gmail.com. 2. Psychiatric University Clinic, Faculdade de Medicina, Universidade de Lisboa, 1649-028, Lisboa, Portugal. ricardomcoentre@gmail.com. 3. Department of Psychiatry, Centro Hospitalar Universitário Lisboa Norte, Av Prof. Egas Moniz, 1649-035, Lisboa, Portugal. 4. Psychiatric University Clinic, Faculdade de Medicina, Universidade de Lisboa, 1649-028, Lisboa, Portugal. 5. Biomathematics Laboratory, Faculdade de Medicina, Universidade de Lisboa, 1649-028, Lisboa, Portugal.
Abstract
BACKGROUND: Suicide is one of the main causes of excess of premature death in psychotic patients. Published studies found that suicide risk begins in ultra-high risk of psychosis and continues in early years of the disease. Previous studies identifying predictive and risk factors associated with suicidality in first-episode psychosis (FEP) are highly inconsistent. Also, there are relatively few longitudinal studies on suicidal behaviour in FEP. The aim of this study was to examine prevalence, evolution and predictors of suicidal behaviour at baseline and the 12-month follow-up in patients presenting with FEP. METHODS: One hundred and eighteen patients presenting with FEP were recruited from two early psychosis units in Portugal. A comprehensive assessment examining socio-demographic and clinical characteristics was administered at baseline and the 12-month follow-up. Odds ratio were calculated using logistic regression analyses. McNemar test was used to evaluate the evolution of suicidal behaviour and depression prevalence from baseline to 12 months of follow-up. RESULTS: Follow-up data were available for 60 participants from the 118 recruited. Approximately 25.4% of the patients had suicidal behaviour at the baseline evaluation, with a significant reduction during the follow-up period to 13.3% (p = 0.035). A multivariate binary logistic regression showed that a history of suicidal behaviour and depression at baseline independently predicted suicidal behaviour at baseline, and a history of suicidal behaviour and low levels of total cholesterol predicted suicidal behaviour at the 12-month follow-up. A significant proportion of patients also had depression at the baseline evaluation (43.3%), with the last month of suicidal behaviour at baseline independently predicting depression at this time. CONCLUSIONS: The findings of our study indicate that suicidal behaviour was prevalent on the year after FEP. Patients with a history of suicidal behaviour, depression at baseline and low levels of cholesterol should undergo close evaluation, monitoring and possible intervention in order to reduce suicide risk in the early phases of psychosis.
BACKGROUND: Suicide is one of the main causes of excess of premature death in psychoticpatients. Published studies found that suicide risk begins in ultra-high risk of psychosis and continues in early years of the disease. Previous studies identifying predictive and risk factors associated with suicidality in first-episode psychosis (FEP) are highly inconsistent. Also, there are relatively few longitudinal studies on suicidal behaviour in FEP. The aim of this study was to examine prevalence, evolution and predictors of suicidal behaviour at baseline and the 12-month follow-up in patients presenting with FEP. METHODS: One hundred and eighteen patients presenting with FEP were recruited from two early psychosis units in Portugal. A comprehensive assessment examining socio-demographic and clinical characteristics was administered at baseline and the 12-month follow-up. Odds ratio were calculated using logistic regression analyses. McNemar test was used to evaluate the evolution of suicidal behaviour and depression prevalence from baseline to 12 months of follow-up. RESULTS: Follow-up data were available for 60 participants from the 118 recruited. Approximately 25.4% of the patients had suicidal behaviour at the baseline evaluation, with a significant reduction during the follow-up period to 13.3% (p = 0.035). A multivariate binary logistic regression showed that a history of suicidal behaviour and depression at baseline independently predicted suicidal behaviour at baseline, and a history of suicidal behaviour and low levels of total cholesterol predicted suicidal behaviour at the 12-month follow-up. A significant proportion of patients also had depression at the baseline evaluation (43.3%), with the last month of suicidal behaviour at baseline independently predicting depression at this time. CONCLUSIONS: The findings of our study indicate that suicidal behaviour was prevalent on the year after FEP. Patients with a history of suicidal behaviour, depression at baseline and low levels of cholesterol should undergo close evaluation, monitoring and possible intervention in order to reduce suicide risk in the early phases of psychosis.
Authors: Elizabeth A Barrett; Kjetil Sundet; Ann Faerden; Ingrid Agartz; Unni Bratlien; Kristin Lie Romm; Erlend Mork; Jan Ivar Rossberg; Nils Eiel Steen; Ole A Andreassen; Ingrid Melle Journal: Schizophr Res Date: 2010-08-03 Impact factor: 4.939
Authors: Wing Chung Chang; Emily Sze Man Chen; Christy Lai Ming Hui; Sherry Kit Wa Chan; Edwin Ho Ming Lee; Eric Yu Hai Chen Journal: Schizophr Res Date: 2014-06-27 Impact factor: 4.939
Authors: S Rigucci; T R Marques; M Di Forti; H Taylor; F Dell'Acqua; V Mondelli; S Bonaccorso; A Simmons; A S David; P Girardi; C M Pariante; R M Murray; P Dazzan Journal: Psychol Med Date: 2015-11-27 Impact factor: 10.592