Vincenza Gianfredi1, Magdalena Beran2, Annemarie Koster3, Simone Jpm Eussen4, Anna Odone5, Carlo Signorelli6, Nicolaas C Schaper2, Sebastian Köhler7, Hans Bosma3, Pieter C Dagnelie8, Coen DA Stehouwer9, Anke Wesselius10, Andrea Amerio11, Stephanie Brinkhues12, Nicole Dukers-Muijrers13, Miranda T Schram14. 1. CAPHRI Care and Public Health Research Institute, Maastricht University, Maastricht, the Netherlands; CARIM School for Cardiovascular Diseases, Maastricht University, Maastricht, the Netherlands; School of Medicine, Vita-Salute San Raffaele University, Milan, Italy. 2. CARIM School for Cardiovascular Diseases, Maastricht University, Maastricht, the Netherlands; Department of Internal Medicine, Maastricht University, Maastricht, the Netherlands. 3. CAPHRI Care and Public Health Research Institute, Maastricht University, Maastricht, the Netherlands; Department of Social Medicine, Maastricht University, Maastricht, the Netherlands. 4. CARIM School for Cardiovascular Diseases, Maastricht University, Maastricht, the Netherlands; Department of Epidemiology; Maastricht University, Maastricht, the Netherlands. 5. Department Public Health, Experimental and Forensic Medicine, University of Pavia, Pavia, Italy. 6. School of Medicine, Vita-Salute San Raffaele University, Milan, Italy. 7. Department of Psychiatry and Neuropsychology, Maastricht University, Maastricht, the Netherlands; MHeNS School for Mental Health and Neuroscience, Maastricht University Medical Center+, Maastricht, the Netherlands. 8. CAPHRI Care and Public Health Research Institute, Maastricht University, Maastricht, the Netherlands; CARIM School for Cardiovascular Diseases, Maastricht University, Maastricht, the Netherlands; Department of Epidemiology; Maastricht University, Maastricht, the Netherlands. 9. Department of Internal Medicine, Maastricht University, Maastricht, the Netherlands; Department of Social Medicine, Maastricht University, Maastricht, the Netherlands. 10. NUTRIM School for Nutrition and Translational Research in Metabolism, University of Maastricht, Department of Complex Genetics, Maastricht University, Maastricht, the Netherlands. 11. Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), Section of Psychiatry, University of Genoa, Genoa, Italy; IRCCS Ospedale Policlinico San Martino, Genoa, Italy; Mood Disorders Program, Tufts Medical Center, Boston, MA, USA. 12. Department of Sexual Health, Infectious Diseases, and Environmental Health, Heerlen, South Limburg Public Health Service, the Netherlands. 13. CAPHRI Care and Public Health Research Institute, Maastricht University, Maastricht, the Netherlands; NUTRIM School for Nutrition and Translational Research in Metabolism, University of Maastricht, Department of Complex Genetics, Maastricht University, Maastricht, the Netherlands; Department of Sexual Health, Infectious Diseases, and Environmental Health, Heerlen, South Limburg Public Health Service, the Netherlands. 14. CARIM School for Cardiovascular Diseases, Maastricht University, Maastricht, the Netherlands; Department of Internal Medicine, Maastricht University, Maastricht, the Netherlands; MHeNS School for Mental Health and Neuroscience, Maastricht University Medical Center+, Maastricht, the Netherlands; Heart and Vascular Center, Maastricht University Medical Center+, Maastricht, the Netherlands. Electronic address: m.schram@maastrichtuniversity.nl.
Abstract
AIMS: Social network characteristics may provide a novel non-pharmaceutical target for the prevention of depression. We investigated the temporal association of a broad range of structural and functional social network characteristics with incident depressive symptoms over 5 years of follow-up. METHODS: We used data from The Maastricht Study, a population-based prospective cohort study (n=2,465, mean age 59.8±8.1 years, 49.1% women, 11,585 person-years of follow-up). Social network characteristics were assessed through a name generator questionnaire. Clinically relevant depressive symptoms (9-item Patient Health Questionnaire score≥10) were assessed at baseline and annually. We used multivariable logistic and Cox regression analyses, adjusted for sociodemographic, lifestyle and cardiovascular risk factors. RESULTS: In cross-sectional analyses less emotional support for discomfort and with important decisions, and less informational support were associated with prevalent depressive symptoms (OR[95%CI] 1.19 [1.01-1.40]; 1.22 [1.05-1.43], and 1.20 [1.04-1.39], respectively). Every fewer 10% of family members was associated with prevalent depressive symptoms (1.11 [1.01-1.23]). In longitudinal analyses, less emotional support on important decisions was also associated with higher risk of incident depressive symptoms (HR[95%CI] 1.13 [1.03-1.25]). In addition, every fewer 10% of the network that was a family member was associated with a higher hazard of incident depressive symptoms (1.07 [1.01-1.13]). CONCLUSIONS: This study shows that less emotional support and fewer family members in the network were associated with higher risk of both prevalent and incident depression. The importance of emotional support and the role that family plays should be considered in treatment and prevention of depression.
AIMS: Social network characteristics may provide a novel non-pharmaceutical target for the prevention of depression. We investigated the temporal association of a broad range of structural and functional social network characteristics with incident depressive symptoms over 5 years of follow-up. METHODS: We used data from The Maastricht Study, a population-based prospective cohort study (n=2,465, mean age 59.8±8.1 years, 49.1% women, 11,585 person-years of follow-up). Social network characteristics were assessed through a name generator questionnaire. Clinically relevant depressive symptoms (9-item Patient Health Questionnaire score≥10) were assessed at baseline and annually. We used multivariable logistic and Cox regression analyses, adjusted for sociodemographic, lifestyle and cardiovascular risk factors. RESULTS: In cross-sectional analyses less emotional support for discomfort and with important decisions, and less informational support were associated with prevalent depressive symptoms (OR[95%CI] 1.19 [1.01-1.40]; 1.22 [1.05-1.43], and 1.20 [1.04-1.39], respectively). Every fewer 10% of family members was associated with prevalent depressive symptoms (1.11 [1.01-1.23]). In longitudinal analyses, less emotional support on important decisions was also associated with higher risk of incident depressive symptoms (HR[95%CI] 1.13 [1.03-1.25]). In addition, every fewer 10% of the network that was a family member was associated with a higher hazard of incident depressive symptoms (1.07 [1.01-1.13]). CONCLUSIONS: This study shows that less emotional support and fewer family members in the network were associated with higher risk of both prevalent and incident depression. The importance of emotional support and the role that family plays should be considered in treatment and prevention of depression.
Authors: Vincenza Gianfredi; Pietro Ferrara; Flavia Pennisi; Giulia Casu; Andrea Amerio; Anna Odone; Daniele Nucci; Monica Dinu Journal: Int J Environ Res Public Health Date: 2022-05-26 Impact factor: 4.614
Authors: Alessandra Costanza; Andrea Amerio; Andrea Aguglia; Gianluca Serafini; Mario Amore; Elena Macchiarulo; Francesco Branca; Roberto Merli Journal: Acta Biomed Date: 2021-10-01
Authors: Daniele Nucci; Omar Enzo Santangelo; Sandro Provenzano; Mariateresa Nardi; Alberto Firenze; Vincenza Gianfredi Journal: Int J Environ Res Public Health Date: 2022-08-18 Impact factor: 4.614