Leopoldo O Tso1, Luciana Leis2, Claudia G Glina2, Cristiano E Busso2, Rodrigo S Romano2, Newton E Busso3, Roberta Wonchockier2, Sidney Glina4. 1. Projeto ALFA/BETA, Aliança de Laboratórios de Fertilização Assistida, R. Cincinato Braga, 37 - 12 Andar - Bela Vista, São Paulo, SP 01333-011, Brazil; Clínica de Reprodução Humana - Departamento de Ginecologia e Obstetrícia da Santa Casa de São Paulo, Rua Dr. Cesário Motta Jr., 112, Vila Buarque, São Paulo, SP 01221-020, Brazil. Electronic address: leopoldotso@gmail.com. 2. Projeto ALFA/BETA, Aliança de Laboratórios de Fertilização Assistida, R. Cincinato Braga, 37 - 12 Andar - Bela Vista, São Paulo, SP 01333-011, Brazil. 3. Projeto ALFA/BETA, Aliança de Laboratórios de Fertilização Assistida, R. Cincinato Braga, 37 - 12 Andar - Bela Vista, São Paulo, SP 01333-011, Brazil; Clínica de Reprodução Humana - Departamento de Ginecologia e Obstetrícia da Santa Casa de São Paulo, Rua Dr. Cesário Motta Jr., 112, Vila Buarque, São Paulo, SP 01221-020, Brazil. 4. Projeto ALFA/BETA, Aliança de Laboratórios de Fertilização Assistida, R. Cincinato Braga, 37 - 12 Andar - Bela Vista, São Paulo, SP 01333-011, Brazil; Disciplina de Urologia - Faculdade de Medicina do ABC, Av. Lauro Gomes, 2000 - Vila Sacadura Cabral, Santo André, SP 09060-870, Brazil.
Abstract
OBJECTIVE: Women undergoing assisted reproductive treatment are usually concerned about the side effects caused by high doses of gonadotropin. A common inquiry of patients is concerning the weight gain as a consequence. The aim of this study was to evaluate if controlled ovarian stimulation increase the weight of women undergoing IVF treatment. Study design This retrospective cohort study included 734 women undergoing IVF treatment between January 2017 and May 2018 and had body weight measured on the day of ovarian stimulation starting (basal-weight) and on the hCG trigger day (hCG-weight). The difference of hCG-weight and basal-weight was calculated and correlated to number of oocytes retrieved and ovarian stimulation protocol. For 358 women, two international validated questionnaires to evaluate the anxiety and binge eating were applied at the end of ovarian stimulation and also associated to the body weight gain. RESULTS: The basal-weight and hCG-weight were paired compared and demonstrate a statistically significant weight gain from basal to hCG-weight of a mean of 387.7 ± 720.4 g (p < 0.001). The weight gain had a positive correlation with the number of oocytes retrieved (Pearson correlation, r = 0.181; p < 0.001) but no correlation with the ovarian stimulation protocol. Regarding the questionnaires answered by patients, neither anxiety score (Pearson: r = -0,031; p = 0,561) nor binge eating score (Pearson: r = 0,069; p = 0,199) were correlated with weight gain from basal-weight to hCG- weight. However, patients who felt eating more during the treatment had a higher weight gain (p < 0.001) independently of the number of oocytes retrieved. CONCLUSIONS: The weight gain is possibly a result from edema and is clinically irrelevant despite of the statistical significance and will probably be resolved in some days after oocytes retrieval. A small "weight gain" was observed and associated to the number of oocytes retrieved regardless of protocol and medication used in the ovarian stimulation.
OBJECTIVE:Women undergoing assisted reproductive treatment are usually concerned about the side effects caused by high doses of gonadotropin. A common inquiry of patients is concerning the weight gain as a consequence. The aim of this study was to evaluate if controlled ovarian stimulation increase the weight of women undergoing IVF treatment. Study design This retrospective cohort study included 734 women undergoing IVF treatment between January 2017 and May 2018 and had body weight measured on the day of ovarian stimulation starting (basal-weight) and on the hCG trigger day (hCG-weight). The difference of hCG-weight and basal-weight was calculated and correlated to number of oocytes retrieved and ovarian stimulation protocol. For 358 women, two international validated questionnaires to evaluate the anxiety and binge eating were applied at the end of ovarian stimulation and also associated to the body weight gain. RESULTS: The basal-weight and hCG-weight were paired compared and demonstrate a statistically significant weight gain from basal to hCG-weight of a mean of 387.7 ± 720.4 g (p < 0.001). The weight gain had a positive correlation with the number of oocytes retrieved (Pearson correlation, r = 0.181; p < 0.001) but no correlation with the ovarian stimulation protocol. Regarding the questionnaires answered by patients, neither anxiety score (Pearson: r = -0,031; p = 0,561) nor binge eating score (Pearson: r = 0,069; p = 0,199) were correlated with weight gain from basal-weight to hCG- weight. However, patients who felt eating more during the treatment had a higher weight gain (p < 0.001) independently of the number of oocytes retrieved. CONCLUSIONS: The weight gain is possibly a result from edema and is clinically irrelevant despite of the statistical significance and will probably be resolved in some days after oocytes retrieval. A small "weight gain" was observed and associated to the number of oocytes retrieved regardless of protocol and medication used in the ovarian stimulation.