Linlin Mai1, Weixing Wen1, Min Qiu1, Xiong Liu1, Lichang Sun1, Haoxiao Zheng1, Xiaoyan Cai2, Yuli Huang1,3,4. 1. Department of Cardiology, Shunde Hospital, Southern Medical University, Foshan, China. 2. Department of Scientific Research and Education, Shunde Hospital, Southern Medical University, Foshan, China. 3. The George Institute for Global Health, Faculty of Medicine, University of New South Wales, Sydney, Australia. 4. Guangdong Provincial Key Laboratory of Shock and Microcirculation, China.
Abstract
AIMS: Heart failure (HF) patients with diabetes experienced significantly worse outcomes than those without diabetes. However, data on the prognostic impact of prediabetes in HF are inconclusive. This meta-analysis aimed to explore the association between prediabetes and the risk of all-cause mortality and adverse cardiac outcomes in HF patients. MATERIALS AND METHODS: We searched multiple electronic databases (PubMed, Embase, and Google Scholar) for relevant studies up to March 31, 2021. Studies were included for analysis if multivariable adjusted relative risks of adverse outcomes were reported in prediabetic HF patients compared with those with normoglycaemia. Random-effects models were used to calculate the pooled hazard ratios (HRs) and 95% confidence intervals (CIs). RESULTS: Twelve studies comprising 28 643 HF patients reported the risk of all-cause mortality and cardiac outcomes associated with prediabetes were included. The prevalence of prediabetes ranged from 9.6% to 37.2%. After a median follow-up duration of 2.3 years, HF patients with prediabetes were associated with an increased risk of all-cause mortality (HR 1.29, 95% CI 1.06-1.58), cardiovascular mortality (HR 1.59, 95% CI 1.09-2.32), HF hospitalization (HR 1.33, 95% CI 1.09-1.61), all-cause mortality and/or HF hospitalization (HR 1.22, 95% CI 1.01-1.47), as well as cardiovascular mortality and/or HF hospitalization (HR 1.21, 95% CI 1.07-1.37), respectively. CONCLUSIONS: Prediabetes is associated with a worse prognosis in patients with HF. Further risk stratification and effective treatment strategies are needed in prediabetic HF patients to improve the prognosis. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.
AIMS: Heart failure (HF) patients with diabetes experienced significantly worse outcomes than those without diabetes. However, data on the prognostic impact of prediabetes in HF are inconclusive. This meta-analysis aimed to explore the association between prediabetes and the risk of all-cause mortality and adverse cardiac outcomes in HF patients. MATERIALS AND METHODS: We searched multiple electronic databases (PubMed, Embase, and Google Scholar) for relevant studies up to March 31, 2021. Studies were included for analysis if multivariable adjusted relative risks of adverse outcomes were reported in prediabetic HFpatients compared with those with normoglycaemia. Random-effects models were used to calculate the pooled hazard ratios (HRs) and 95% confidence intervals (CIs). RESULTS: Twelve studies comprising 28 643 HF patients reported the risk of all-cause mortality and cardiac outcomes associated with prediabetes were included. The prevalence of prediabetes ranged from 9.6% to 37.2%. After a median follow-up duration of 2.3 years, HF patients with prediabetes were associated with an increased risk of all-cause mortality (HR 1.29, 95% CI 1.06-1.58), cardiovascular mortality (HR 1.59, 95% CI 1.09-2.32), HF hospitalization (HR 1.33, 95% CI 1.09-1.61), all-cause mortality and/or HF hospitalization (HR 1.22, 95% CI 1.01-1.47), as well as cardiovascular mortality and/or HF hospitalization (HR 1.21, 95% CI 1.07-1.37), respectively. CONCLUSIONS:Prediabetes is associated with a worse prognosis in patients with HF. Further risk stratification and effective treatment strategies are needed in prediabetic HFpatients to improve the prognosis. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.
Authors: Musa Ado Bashir; Anas Ibrahim Yahaya; Mukhtar Muhammad; Ashiru Hassan Yusuf; Isyaku Gwarzo Mukhtar Journal: Front Public Health Date: 2021-12-23