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Literature DB >> 3422575

Secondary leukemia after severe aplastic anemia.

A Tichelli¹, A Gratwohl, A Würsch, C Nissen, B Speck.

Abstract

We describe a patient with acute myeloid leukemia (AML) occurring 5 years after successful treatment of severe aplastic anemia (SAA) with antilymphocyte globulin (ALG). Four years after ALG, SAA had relapsed. A second remission of SAA was achieved, but was followed by transformation of the myelodysplastic syndrome into overt AML. After 2 courses of high-dose cytosine arabinoside and VP-16 complete remission occurred. This case shows that chemotherapy of secondary leukemia after SAA is feasible, and that ex-aplastic bone marrow is capable of complete recovery from chemotherapy-induced aplasia. Morphological anomalies of bone marrow noticed early during remission of SAA might predict a late transformation in leukemia.

Entities: Chemical Disease Gene Species

Mesh：

Substances：
Antilymphocyte Serum

Year: 1988 PMID： 3422575 DOI： 10.1007/BF00633468

Source DB: PubMed Journal: Blut ISSN： 0006-5242

13 in total

Review 1. Acute leukemia as a terminal event in nonleukemic hematopoietic disorders.

Authors: C D Bloomfield; R D Brunning
Journal: Semin Oncol Date: 1976-09 Impact factor: 4.929

2. Transformation of Fanconi's anemia to acute nonlymphocytic leukemia associated with emergence of monosomy 7.

Authors: T J Stivrins; R B Davis; W Sanger; J Fritz; D T Purtilo
Journal: Blood Date: 1984-07 Impact factor: 22.113

3. Treatment of severe aplastic anaemia with antilymphocyte globulin or bone-marrow transplantation.

Authors: B Speck; A Gratwohl; C Nissen; U Leibundgut; D Ruggero; B Osterwalder; H P Burri; P Cornu; M Jeannet
Journal: Br Med J (Clin Res Ed) Date: 1981-03-14

4. Peripheral blood cells from patients wih aplastic anaemia in partial remission suppress growth of their own bone marrow precursors in culture.

Authors: C Nissen; P Cornu; A Gratwohl; B Speck
Journal: Br J Haematol Date: 1980-06 Impact factor: 6.998

5. Studies on pure red cell aplasia. X. Association with acute leukemia and significance of bone marrow karyotype abnormalities.

Authors: E N Dessypris; A Fogo; M Russell; E Engel; S B Krantz
Journal: Blood Date: 1980-09 Impact factor: 22.113

6. Proposals for the classification of the myelodysplastic syndromes.

Authors: J M Bennett; D Catovsky; M T Daniel; G Flandrin; D A Galton; H R Gralnick; C Sultan
Journal: Br J Haematol Date: 1982-06 Impact factor: 6.998

7. Aplastic anaemia and the hypocellular myelodysplastic syndrome: histomorphological, diagnostic, and prognostic features.

Authors: I Fohlmeister; R Fischer; B Mödder; M Rister; H E Schaefer
Journal: J Clin Pathol Date: 1985-11 Impact factor: 3.411

Secondary leukemia after severe aplastic anemia.

Review 1. Acute leukemia as a terminal event in nonleukemic hematopoietic disorders.

2. Transformation of Fanconi's anemia to acute nonlymphocytic leukemia associated with emergence of monosomy 7.

3. Treatment of severe aplastic anaemia with antilymphocyte globulin or bone-marrow transplantation.

4. Peripheral blood cells from patients wih aplastic anaemia in partial remission suppress growth of their own bone marrow precursors in culture.

5. Studies on pure red cell aplasia. X. Association with acute leukemia and significance of bone marrow karyotype abnormalities.

6. Proposals for the classification of the myelodysplastic syndromes.

7. Aplastic anaemia and the hypocellular myelodysplastic syndrome: histomorphological, diagnostic, and prognostic features.

8. Erythroleukemia following drug induced hypoplastic anemia.

9. Aplastic anaemia: an analysis of 174 patients.

10. Congenital hypoplastic anemia (Diamond-Blackfan syndrome) terminating in acute myelogenous leukemia.

1. Secondary myelodysplastic syndrome and leukemia in acquired aplastic anemia and paroxysmal nocturnal hemoglobinuria.