Xiao-Hui Zhang1,2, Pei-Zhen Zhao1,2, Wu-Jian Ke1,2, Liu-Yuan Wang1,2, Lai Sze Tso3,4,5, Zheng-Yu Chen1,2, Yu-Ying Liao1,2, Chun-Mei Liang1,2, Hui-Ru Chen1,2, Xu-Qi Ren1,2, Jin-Mei Huang1,2, Jason J Ong6,7, Fan Yang8, Li-Gang Yang9,10. 1. Dermatology Hospital, Southern Medical University, Guangdong Province, Guangzhou, China. 2. Guangdong Provincial Dermatology Hospital, Guangdong Provincial Center for Skin Diseases and STD Control, Guangzhou, China. 3. Department of Culture Studies and Oriental Languages, University of Oslo, Oslo, Norway. 4. Anthropology, Massachusetts Institute of Technology, Cambridge, MA, USA. 5. Center for Health and Human Development Studies, Sun Yat-sen University, Guangzhou, Guangdong, China. 6. Clinical Research Department, London School of Hygiene and Tropical Medicine, London, UK. 7. Central Clinical School, Monash University, Melbourne, Australia. 8. University of North Carolina, UNC Project-China, Guangzhou, China. 9. Dermatology Hospital, Southern Medical University, Guangdong Province, Guangzhou, China. yanglg3@hotmail.com. 10. Guangdong Provincial Dermatology Hospital, Guangdong Provincial Center for Skin Diseases and STD Control, Guangzhou, China. yanglg3@hotmail.com.
Abstract
BACKGROUND: Mycoplasma genitalium (MG) causes urogenital tract infections and is associated with reproductive morbidity. Although MG has been reported across many regions and population groups, it is not yet routinely tested for in China. Our study contributes to current research by reporting the prevalence and correlates of MG infection in patients attending a sexually transmitted infection (STI) clinic in Guangdong from Jan 2017-May 2018. METHODS: Urethral (from 489 men) and endo-cervical (from 189 women) samples, blood samples, and patient histories (via questionnaires) were collected. Doctors clinically diagnosed anogenital warts (GW) during the examination (n = 678). The presence of MG was evaluated using an in-house via polymerase chain reaction protocol. We also tested all participants for herpes simplex virus-2 (HSV-2), Neisseria gonorrhoeae (NG), Chlamydia trachomatis (CT), syphilis and HIV. Univariate and multivariate logistic regression were used to evaluate factors associated with MG. RESULTS: MG was detected in 7.2% (49/678) of the patients (men, 7.4%; women, 6.9%). The MG positivity rate was 14.2% among symptomatic patients, and 5.6% for asymptomatic patients, respectively. Only 36.7% (18/49) Mg positive patients were symptomatic. Among the MG-infected patients, 10.2% were co-infected with CT, 6.1% with NG, 8.2% with HSV-2, 4.1% with syphilis and 22.4% with GW. Presentation with clinical symptoms was significantly associated with MG infection [OR = 2.52 (2.03-3.13)]. In our analysis, MG was not associated with other STIs. CONCLUSIONS: MG is a relatively common infection among individuals attending an STI clinic in Guangdong Province. Routine testing of symptomatic patients may be necessary, and more epidemiological studies are needed to provide evidence for future testing guidelines.
BACKGROUND:Mycoplasma genitalium (MG) causes urogenital tract infections and is associated with reproductive morbidity. Although MG has been reported across many regions and population groups, it is not yet routinely tested for in China. Our study contributes to current research by reporting the prevalence and correlates of MG infection in patients attending a sexually transmitted infection (STI) clinic in Guangdong from Jan 2017-May 2018. METHODS: Urethral (from 489 men) and endo-cervical (from 189 women) samples, blood samples, and patient histories (via questionnaires) were collected. Doctors clinically diagnosed anogenital warts (GW) during the examination (n = 678). The presence of MG was evaluated using an in-house via polymerase chain reaction protocol. We also tested all participants for herpes simplex virus-2 (HSV-2), Neisseria gonorrhoeae (NG), Chlamydia trachomatis (CT), syphilis and HIV. Univariate and multivariate logistic regression were used to evaluate factors associated with MG. RESULTS:MG was detected in 7.2% (49/678) of the patients (men, 7.4%; women, 6.9%). The MG positivity rate was 14.2% among symptomatic patients, and 5.6% for asymptomatic patients, respectively. Only 36.7% (18/49) Mg positive patients were symptomatic. Among the MG-infectedpatients, 10.2% were co-infected with CT, 6.1% with NG, 8.2% with HSV-2, 4.1% with syphilis and 22.4% with GW. Presentation with clinical symptoms was significantly associated with MG infection [OR = 2.52 (2.03-3.13)]. In our analysis, MG was not associated with other STIs. CONCLUSIONS:MG is a relatively common infection among individuals attending an STI clinic in Guangdong Province. Routine testing of symptomatic patients may be necessary, and more epidemiological studies are needed to provide evidence for future testing guidelines.
Authors: Jason J Ong; Ei Aung; Tim R H Read; Christopher K Fairley; Suzanne M Garland; Gerald Murray; Marcus Y Chen; Eric P F Chow; Catriona S Bradshaw Journal: Sex Transm Dis Date: 2018-08 Impact factor: 2.830
Authors: Dino Papeš; Miram Pasini; Ana Jerončić; Martina Vargović; Viktor Kotarski; Alemka Markotić; Višnja Škerk Journal: Int J STD AIDS Date: 2017-01-25 Impact factor: 1.359