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Literature DB >> 34223909

Limited neutralization of authentic SARS-CoV-2 variants carrying E484K in vitro.

Marek Widera¹, Alexander Wilhelm¹, Sebastian Hoehl¹, Christiane Pallas¹, Niko Kohmer¹, Timo Wolf^2,3, Holger F Rabenau¹, Victor M Corman^4,5, Christian Drosten^4,5, Maria J G T Vehreschild^2,3, Udo Goetsch⁶, Rene Gottschalk⁶, Sandra Ciesek^1,5,7.

Abstract

Whether monoclonal antibodies are able to neutralise SARS-CoV-2 variants of concern has been investigated using pseudoviruses. In this study we show that bamlanivimab, casirivimab, and imdevimab efficiently neutralise authentic SARS-CoV-2 including variant B.1.1.7 (Alpha) but variants B.1.351 (Beta) and P.2 (Zeta) were resistant against bamlanivimab and partially to casirivimab.

Entities: Chemical Mutation Species

Keywords: SARS-CoV-2; bamlanivimab; casirivimab; corona virus; imdevinab; monoclonal antibodies

Year: 2021 PMID： 34223909 DOI： 10.1093/infdis/jiab355

Source DB: PubMed Journal: J Infect Dis ISSN： 0022-1899 Impact factor: 5.226

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7. Single-Amplicon Multiplex Real-Time Reverse Transcription-PCR with Tiled Probes To Detect SARS-CoV-2 spike Mutations Associated with Variants of Concern.

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8. Emergence of the E484K mutation in SARS-COV-2-infected immunocompromised patients treated with bamlanivimab in Germany.

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