| Literature DB >> 34223590 |
Montassar Khalil1, Dany Jeanne Dit Fouque1, Mathieu Berchel1, Aurore Fraix2, Aurélien Dupont3, Salvatore Sortino2, Antony Memboeuf1, Paul-Alain Jaffrès1.
Abstract
The incorporation of lipophilic phosphonodithioesters in phospholipid formulations generates clickable liposomes that react with amines. The kinetics of this metal free phosphonodithioester-amine coupling (PAC) on liposomes in water is reported and can be classified as a fast reaction with a second order rate constant of k ≈ 8 × 102 M-1 s-1. The PAC reaction represents a versatile strategy to functionalize liposomes.Entities:
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Year: 2021 PMID： 34223590 DOI： 10.1039/d1ob01078f
Source DB: PubMed Journal: Org Biomol Chem ISSN： 1477-0520 Impact factor: 3.876