Literature DB >> 34223164

A mimotope attached to an ITIM-SHP-1 interaction inhibitory peptide boosts immune response and efficacy.

Koushik Roy1, Syamal Roy2, Siddhartha Roy3.   

Abstract

Antigen binding to the B-cell receptor initiates a downstream signalling pathway that contains both stimulatory and damping components. A malarial parasite-derived conformation-constrained peptide was conjugated to a signal-damping pathway inhibitor. Mice immunized with this antigen produced higher antibody levels which delayed parasitemia. This represents a new approach to antigen design. This journal is © The Royal Society of Chemistry.

Entities:  

Year:  2021        PMID： 34223164      PMCID： PMC8221254          DOI： 10.1039/d1md00099c

Source DB:  PubMed          Journal:  RSC Med Chem        ISSN： 2632-8682


  25 in total

1.  Exploiting conformationally constrained peptidomimetics and an efficient human-compatible delivery system in synthetic vaccine design.

Authors:  R Moreno; L Jiang; K Moehle; R Zurbriggen; R Glück; J A Robinson; G Pluschke
Journal:  Chembiochem       Date:  2001-11-05       Impact factor: 3.164

Review 2.  B cell antigen receptor signaling 101.

Authors:  Joseph M Dal Porto; Stephen B Gauld; Kevin T Merrell; David Mills; Aimee E Pugh-Bernard; John Cambier
Journal:  Mol Immunol       Date:  2004-07       Impact factor: 4.407

3.  Elicitation of structure-specific antibodies by epitope scaffolds.

Authors:  Gilad Ofek; F Javier Guenaga; William R Schief; Jeff Skinner; David Baker; Richard Wyatt; Peter D Kwong
Journal:  Proc Natl Acad Sci U S A       Date:  2010-09-27       Impact factor: 11.205

Review 4.  Inhibitory receptors, ITIM sequences and phosphatases.

Authors:  J C Unkeless; J Jin
Journal:  Curr Opin Immunol       Date:  1997-06       Impact factor: 7.486

5.  Carrier protein influences immunodominance of a known epitope: implication in peptide vaccine design.

Authors:  Moumita Ghosh; Ashish K Solanki; Koushik Roy; Reema R Dhoke; Syamal Roy
Journal:  Vaccine       Date:  2013-08-05       Impact factor: 3.641

6.  Fc receptor-like 5 inhibits B cell activation via SHP-1 tyrosine phosphatase recruitment.

Authors:  Christopher L Haga; Götz R A Ehrhardt; Rebecca J Boohaker; Randall S Davis; Max D Cooper
Journal:  Proc Natl Acad Sci U S A       Date:  2007-05-23       Impact factor: 11.205

Review 7.  Of ITAMs and ITIMs: turning on and off the B cell antigen receptor.

Authors:  M L Thomas
Journal:  J Exp Med       Date:  1995-06-01       Impact factor: 14.307

Review 8.  Peptide-based synthetic vaccines.

Authors:  Mariusz Skwarczynski; Istvan Toth
Journal:  Chem Sci       Date:  2015-12-17       Impact factor: 9.825

9.  Early phase II study of mixed 19-peptide vaccine monotherapy for refractory triple-negative breast cancer.

Authors:  Uhi Toh; Sayaka Sakurai; Shuko Saku; Yuko Takao; Mina Okabe; Nobutaka Iwakuma; Shigeki Shichijo; Akira Yamada; Kyogo Itoh; Yoshito Akagi
Journal:  Cancer Sci       Date:  2020-06-25       Impact factor: 6.716

Review 10.  Malaria vaccines since 2000: progress, priorities, products.

Authors:  Patrick E Duffy; J Patrick Gorres
Journal:  NPJ Vaccines       Date:  2020-06-09       Impact factor: 7.344
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