Literature DB >> 34221699

Correction: Can Plasma α-Synuclein Help Us to Differentiate Parkinson's Disease from Essential Tremor?

Silvia M Albillos¹, Olimpio Montero², Sara Calvo³, Berta Solano⁴, José María Trejo⁵, Esther Cubo⁵.

Abstract

[This corrects the article DOI: 10.5334/tohm.600.]. Copyright:

Entities: Disease Gene Species

Keywords: Essential tremor; Parkinson’s disease; alpha-synuclein; diagnosis; plasma biomarker

Year: 2021 PMID： 34221699 PMCID： PMC8231448 DOI： 10.5334/tohm.637

Source DB: PubMed Journal: Tremor Other Hyperkinet Mov (N Y) ISSN： 2160-8288

Correction

In of Albillos et al. [1] there is no Off-State N = 33 value of NMSS total score and of PDCRS total score. Comparison of participant’s characteristics. Values are expressed in medians (interquartile range) otherwise specified a = mean (Standard deviation). Parkinson’s disease (PD) (total sample = 35) measured in the ON state (ON-PD) (n = 35) and OFF state (OFF-PF), (n = 33); ET = Essential Tremor; UPDRS = Unified Parkinson’s disease Rating Scale; NMSS = Non motor symptoms severity score: PDCRS = Parkinson’s disease cognitive rating scale. Data were compared using the ANOVA test. In , the values of α-Synuclein are quoted in ng/ml. The label of the first cell of the last row is ‘Pairwise comparisons’ and should read (1) vs. (5), (2) vs. (4), and (3) vs. (5) (second cell), (1) vs. (2) and (1) vs. (3) (third cell) and (1) vs. (2), (1) vs. (4), and (3) vs. (4) (fifth cell). Plasma α-synuclein quantitation (ng/ml) stratified by age and gender. SD = Standard deviation. Age was stratified based on the median distribution of the total sample. * Pairwise intra-group comparisons as indicated in each column; n.s = not significant. The correct tables are included here. This information was not included correctly in the final versions sent by the authors.

Table 1

Comparison of participant’s characteristics.


	NOVO-PDN = 19	PDN = 35		ETN = 19	CONTROLSN = 35	P-VALUE

		ON-STATE	OFF-STATE

Males (%)	13 (68)	24 (69)	22 (67)	12 (63)	11 (31)	0.01

Age (years)^a	66.9 (8.8)	64.5 (9.1)	64.1 (9.0)	70.8 (6.7)	61.4 (7.3)	0.002

Disease duration (years)	1 (0.6; 3)	10 (2; 25)	–	7 (1; 29)	–	–

UPDRS-III score	20 (8; 41)	24 (5; 49)	35 (12; 70)	–	–	0.01

NMSS total score	42 (24; 86)	69 (12; 119)	–	–	–	0.08

PDCRS total score	74 (58; 112)	80 (43; 109)	–	–	–	0.91

Values are expressed in medians (interquartile range) otherwise specified a = mean (Standard deviation). Parkinson’s disease (PD) (total sample = 35) measured in the ON state (ON-PD) (n = 35) and OFF state (OFF-PF), (n = 33); ET = Essential Tremor; UPDRS = Unified Parkinson’s disease Rating Scale; NMSS = Non motor symptoms severity score: PDCRS = Parkinson’s disease cognitive rating scale. Data were compared using the ANOVA test.

Table 2

Plasma α-synuclein quantitation (ng/ml) stratified by age and gender.


GROUPS	α-SYNUCLEIN (ng/ml)MEAN ± SD		p-VALUE	α-SYNUCLEIN (ng/ml)MEAN ± SD		P-VALUE

	MEN(n)	WOMEN(n)		<66 YEARS OLD(n)	≥66 YEARS OLD(n)

CONTROL ₍₁₎	158.40 ± 102.95(11)	177.12 ± 86.53(24)	0.57	174.81 ± 94.85(25)	162.32 ± 84.18(10)	0.71

ON-PD ₍₂₎	112.30 ± 56.63(23)	111.08 ± 40.45(10)	0.95	125.76 ± 56.77(17)	97.24 ± 42.45(16)	0.11

OFF-PD ₍₃₎	128.64 ± 46.37(21)	127.26 ± 29.16(10)	0.92	137.40 ± 43.43(16)	118.37 ± 37.40(15)	0.20

NOVO-PD ₍₄₎	91.92 ± 35.28(13)	131.25 ± 50.01(6)	0.06	90.21 ± 26.38(7)	112.58 ± 49.91(12)	0.21

ET ₍₅₎	79.74 ± 32.11(12)	143.73 ± 71.89(6)	0.08	54.33 ± 1.95(2)	106.92 ± 56.94(16)

Pairwise comparisons	(1) vs. (5)(2) vs. (4)(3) vs. (5)	(1) vs. (2)(1) vs. (3)	<0.05*	(1) vs. (2)(1) vs. (4)(3) vs. (4)	n.s	<0.05*

SD = Standard deviation. Age was stratified based on the median distribution of the total sample. * Pairwise intra-group comparisons as indicated in each column; n.s = not significant.

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1. Can Plasma α-Synuclein Help Us to Differentiate Parkinson's Disease from Essential Tremor?

Authors: Silvia M Albillos; Olimpio Montero; Sara Calvo; Berta Solano; José María Trejo; Esther Cubo
Journal: Tremor Other Hyperkinet Mov (N Y) Date: 2021-05-28

1 in total