Kelly Segars1,2, Victoria McCarver1,2, Richard A Miller1,2. 1. Dr. Segars is with the Nova Southeastern University: College of Osteopathic Medicine and Largo Medical Center Department of Dermatology in Largo, Florida. 2. Drs. McCarver and Miller are with HCA Healthcare/USF Morsani College of Medicine at Largo Medical Center in Largo, Florida.
Abstract
BACKGROUND: Polypodium leucotomos (PL) is a natural extract from tropical fern leaves with antioxidant and anti-inflammatory properties. It has been implicated as a potential treatment agent in multiple dermatologic conditions. OBJECTIVE: Here, we review the mechanism of action and current dermatologic applications of PL and extrapolate potential future dermatologic applications of PL. DESIGN: An extensive literature review on Pubmed was conducted in search of relevant background information and human studies utilizing PL for the treatment of dermatologic conditions. METHODS: Using the PubMed database, a literature search was conducted to identify relevant publications. "Polypodium leucotomos" was input as the key search criterion. The results were filtered by species (human) and language (English). Only papers with dermatologic applications were selected. Additionally, relevant publications found in the reference sections of selected articles were manually searched and selected. Included articles explore the origin, basic science mechanism, and various dermatologic applications of PL studied in humans. Each article was thoroughly studied by all authors and applicable data from each was used for the compilation of this review article. RESULTS: See Table 1 for a summary of dermatologic applications of PL based on available human clinical studies. LIMITATIONS: There was a limited number of human studies concerning the use of PL for treatment of dermatologic conditions and, of the available studies, many were of a small sample size. CONCLUSION: PL has a clinically significant role for the treatment and prevention of certain dermatologic conditions including: photoprotection, photocarcinogenesis, photoaging, vitiligo, melasma, and polymorphic light eruption. There is supporting evidence for its use in malignant melanoma high-risk patients, for enhanced actinic keratosis clearance following photodynamic therapy, and for symptomatic relief in atopic dermatitis. Potential clinical uses that require additional human clinical studies include solar urticaria, post-inflammatory hyperpigmentation, cutaneous lupus erythematosus, and other photosensitive cutaneous disorders.
BACKGROUND: Polypodium leucotomos (PL) is a natural extract from tropical fern leaves with antioxidant and anti-inflammatory properties. It has been implicated as a potential treatment agent in multiple dermatologic conditions. OBJECTIVE: Here, we review the mechanism of action and current dermatologic applications of PL and extrapolate potential future dermatologic applications of PL. DESIGN: An extensive literature review on Pubmed was conducted in search of relevant background information and human studies utilizing PL for the treatment of dermatologic conditions. METHODS: Using the PubMed database, a literature search was conducted to identify relevant publications. "Polypodium leucotomos" was input as the key search criterion. The results were filtered by species (human) and language (English). Only papers with dermatologic applications were selected. Additionally, relevant publications found in the reference sections of selected articles were manually searched and selected. Included articles explore the origin, basic science mechanism, and various dermatologic applications of PL studied in humans. Each article was thoroughly studied by all authors and applicable data from each was used for the compilation of this review article. RESULTS: See Table 1 for a summary of dermatologic applications of PL based on available human clinical studies. LIMITATIONS: There was a limited number of human studies concerning the use of PL for treatment of dermatologic conditions and, of the available studies, many were of a small sample size. CONCLUSION:PL has a clinically significant role for the treatment and prevention of certain dermatologic conditions including: photoprotection, photocarcinogenesis, photoaging, vitiligo, melasma, and polymorphic light eruption. There is supporting evidence for its use in malignant melanoma high-risk patients, for enhanced actinic keratosis clearance following photodynamic therapy, and for symptomatic relief in atopic dermatitis. Potential clinical uses that require additional human clinical studies include solar urticaria, post-inflammatory hyperpigmentation, cutaneous lupus erythematosus, and other photosensitive cutaneous disorders.
Authors: Ammar M Ahmed; Isha Lopez; Francisco Perese; Rebecca Vasquez; Linda S Hynan; Benjamin Chong; Amit G Pandya Journal: JAMA Dermatol Date: 2013-08 Impact factor: 10.282
Authors: Adriana Villa; Martha H Viera; Sadegh Amini; Ran Huo; Oliver Perez; Phillip Ruiz; Alexandra Amador; George Elgart; Brian Berman Journal: J Am Acad Dermatol Date: 2010-03 Impact factor: 11.527
Authors: P Aguilera; C Carrera; J A Puig-Butille; C Badenas; M Lecha; S González; J Malvehy; S Puig Journal: J Eur Acad Dermatol Venereol Date: 2012-07-31 Impact factor: 6.166
Authors: Janet E Lubov; Aisha S Jamison; Becky Baltich Nelson; Alice A Amudzi; Kelly N Haas; Jillian M Richmond Journal: Front Pharmacol Date: 2022-03-31 Impact factor: 5.988
Authors: Ana Mariel Torres-Contreras; Antoni Garcia-Baeza; Heriberto Rafael Vidal-Limon; Isaias Balderas-Renteria; Mónica A Ramírez-Cabrera; Karla Ramirez-Estrada Journal: Plants (Basel) Date: 2022-01-15
Authors: Diana I S P Resende; Ana Jesus; José M Sousa Lobo; Emília Sousa; Maria T Cruz; Honorina Cidade; Isabel F Almeida Journal: Pharmaceuticals (Basel) Date: 2022-03-18